We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App




New Biologic Repair Patch Uses Natural Body Motion to Fix Herniated Discs

By HospiMedica International staff writers
Posted on 22 Nov 2023
Print article
Image: The tension-activated repair patch plugs holes in discs in the spine like car tire patches (Photo courtesy of Penn Medicine)
Image: The tension-activated repair patch plugs holes in discs in the spine like car tire patches (Photo courtesy of Penn Medicine)

Spinal herniation, a condition where a spinal disc develops a rupture or tear leading to the squeezing out of its soft core, results in the disc losing its ability to cushion the spine effectively, causing pain. Currently, there are no definitive treatments to cure disc herniation. However, a new development known as the tension-activated repair patch (TARP) has shown promise in animal studies. This innovative technology functions similarly to a tire patch for a car, sealing disc ruptures in the spine and potentially halting further disease progression.

Developed by a team at Penn Medicine (Philadelphia, PA, USA), this biologic "patch" activates through the natural movement of the body, potentially offering a solution to repairing herniated spinal discs. TARPS, which was developed by the team after leveraging extensive research from various projects, gradually release an anti-inflammatory agent called anakinra from embedded microcapsules. This release helps the discs in a large animal model to restore their necessary tension, reversing the herniation and preventing further degeneration. The design of TARPs aims not only to seal the tear but also to rebuild the disc's tension and re-establish its cushioning function between the vertebrae, a challenge that has been difficult to overcome until now.

The innovation of TARP lies in its activation through the body’s natural movements, which trigger the release of the anti-inflammatory molecules from the microcapsules. Although theoretically effective even with minimal movement, the nature of disc tissue requires regular motion. The effectiveness of the patch is such that it creates a scenario where the disc tear never existed, potentially playing a crucial role in preventing the escalation of pain associated with disc degeneration. This potential treatment, applicable in both human and veterinary medicine, builds upon the foundational technologies previously used by the research team in creating bio-synthetic discs and other mechanically-activated drug delivery systems. While the research is in its early stages and has demonstrated initial proof of concept, advancing this treatment toward human clinical use will require extended trials in larger animal models, according to the research team.

“This is designed to be an early intervention that may change the course of disease progression,” said co-senior author Harvey Smith, MD. “Currently there’s no treatment to mitigate recurring herniations that actually heal the disc. So we’re looking at a disease that is very common in younger, working-age people that, downstream, leads to severe disc disease and the need for spinal fusion. The more we can prevent that, the better.”

Related Links:
Penn Medicine

Gold Member
SARS‑CoV‑2/Flu A/Flu B/RSV Sample-To-Answer Test
SARS‑CoV‑2/Flu A/Flu B/RSV Cartridge (CE-IVD)
Gold Member
Solid State Kv/Dose Multi-Sensor
AGMS-DM+
Silver Member
Wireless Mobile ECG Recorder
NR-1207-3/NR-1207-E
New
Electrosurgical Unit
es 120

Print article

Channels

Critical Care

view channel
Image: Detecting heart diseases using AI and the ECG (Photo courtesy of 123RF)

AI Technology Boosts ECG Capabilities for Early Heart Disease Diagnosis

Cardiovascular diseases often remain undetected until a critical event like a heart attack or stroke occurs. Early identification is key to improving outcomes, but the absence of clear symptoms complicates... Read more

Patient Care

view channel
Image: The newly-launched solution can transform operating room scheduling and boost utilization rates (Photo courtesy of Fujitsu)

Surgical Capacity Optimization Solution Helps Hospitals Boost OR Utilization

An innovative solution has the capability to transform surgical capacity utilization by targeting the root cause of surgical block time inefficiencies. Fujitsu Limited’s (Tokyo, Japan) Surgical Capacity... Read more

Health IT

view channel
Image: First ever institution-specific model provides significant performance advantage over current population-derived models (Photo courtesy of Mount Sinai)

Machine Learning Model Improves Mortality Risk Prediction for Cardiac Surgery Patients

Machine learning algorithms have been deployed to create predictive models in various medical fields, with some demonstrating improved outcomes compared to their standard-of-care counterparts.... Read more

Point of Care

view channel
Image: The new eye-safe laser technology can diagnose traumatic brain injury (Photo courtesy of 123RF)

Novel Diagnostic Hand-Held Device Detects Known Biomarkers for Traumatic Brain Injury

The growing need for prompt and efficient diagnosis of traumatic brain injury (TBI), a major cause of mortality globally, has spurred the development of innovative diagnostic technologies.... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.