We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Sekisui Diagnostics UK Ltd.

Download Mobile App

Hemostatic Agent Derived From Mussels and Silkworm Cocoons Stops Organ Bleeding

By HospiMedica International staff writers
Posted on 26 Feb 2024
Print article
Image: Absorbent bilayer nanofiber membrane adhesive hemostatic dressing based on mussel adhesion protein and silkworm silk protein (Photo courtesy of POSTECH)
Image: Absorbent bilayer nanofiber membrane adhesive hemostatic dressing based on mussel adhesion protein and silkworm silk protein (Photo courtesy of POSTECH)

Gauze is commonly used in medical procedures for managing bleeding and assisting in hemostasis. However, if left inside the body by mistake, it can cause inflammation and infection. Now, researchers have derived a hemostatic agent from mussels and silkworm cocoons while demonstrating its efficacy in clotting blood and safety within the body.

Traditional hemostatic agents, like gauze or medical bands, are primarily used on the skin's surface. While there are materials that naturally decompose inside the body, such as fibrin glue and collagen sponges, they require proteins from human or animal sources, making them quite expensive. Additionally, current hemostatic materials often fail to consistently stick to bleeding sites and are vulnerable to infection from external contaminants. To tackle these challenges, a joint research team from Pohang University of Science & Technology (POSTECH, Gyeongbuk, Korea) has created a bilayer adhesive hemostat. This new development combines mussel adhesive proteins, known for their strong tissue adhesion underwater, with silk fibroin derived from silkworm cocoons.

Their research showed that mussel adhesive proteins have impressive hemostatic properties, including the activation of platelets. The team used methanol vapor to alter the secondary structure of the silk proteins from silkworms, creating a nanofiber membrane with a hydrophobic exterior. They designed a hemostatic agent with an inner layer of mussel adhesion proteins for attaching to wounds, and an outer layer made entirely of silkworm silk proteins. In animal tests, this hemostatic agent quickly enhanced tissue adhesion and hemostasis in bleeding wounds, effectively blocking water-borne infectious agents like bacteria from entering. This innovative hemostatic agent, using two highly biocompatible and biodegradable proteins, introduces a new approach to blood clotting and infection prevention.

"We have validated the exceptional hemostatic performance of a multifunctional topical adhesive hemostatic agent that is derived from nature and is based on degradable proteins in the human body," said Professor Hyung Joon Cha of the POSTECH who led the study. "We will continue further research to assess its applicability in real-world patient care or surgical settings."

Related Links:

Gold Member
12-Channel ECG
Gold Member
SARS‑CoV‑2/Flu A/Flu B/RSV Sample-To-Answer Test
SARS‑CoV‑2/Flu A/Flu B/RSV Cartridge (CE-IVD)
Silver Member
Wireless Mobile ECG Recorder
Digital Radiography Generator
meX+20BT lite

Print article


Patient Care

view channel
Image: The newly-launched solution can transform operating room scheduling and boost utilization rates (Photo courtesy of Fujitsu)

Surgical Capacity Optimization Solution Helps Hospitals Boost OR Utilization

An innovative solution has the capability to transform surgical capacity utilization by targeting the root cause of surgical block time inefficiencies. Fujitsu Limited’s (Tokyo, Japan) Surgical Capacity... Read more

Health IT

view channel
Image: First ever institution-specific model provides significant performance advantage over current population-derived models (Photo courtesy of Mount Sinai)

Machine Learning Model Improves Mortality Risk Prediction for Cardiac Surgery Patients

Machine learning algorithms have been deployed to create predictive models in various medical fields, with some demonstrating improved outcomes compared to their standard-of-care counterparts.... Read more

Point of Care

view channel
Image: The Quantra Hemostasis System has received US FDA special 510(k) clearance for use with its Quantra QStat Cartridge (Photo courtesy of HemoSonics)

Critical Bleeding Management System to Help Hospitals Further Standardize Viscoelastic Testing

Surgical procedures are often accompanied by significant blood loss and the subsequent high likelihood of the need for allogeneic blood transfusions. These transfusions, while critical, are linked to various... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.