We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Sekisui Diagnostics UK Ltd.

Download Mobile App




Nanosurgical Tool Performs Biopsy of Living Cell Repeatedly during Exposure to Cancer Treatment

By HospiMedica International staff writers
Posted on 08 Mar 2024
Print article
Image: Electron microscopy image of the nanopipette (Photo courtesy of University of Leeds)
Image: Electron microscopy image of the nanopipette (Photo courtesy of University of Leeds)

Cancer cell plasticity, a phenomenon wherein cells alter their behavior, poses a significant challenge in cancer therapy, especially since it is not well understood. This adaptability is particularly evident in Glioblastoma (GBM) cancer cells, known for their rapid adaptation, leading to resistance against radiotherapy and chemotherapy. Understanding these adaptive mechanisms and finding ways to counter them could be pivotal in preventing cancer recurrence, a common issue with GBM. Traditional single-cell study methods usually destroy the cells during analysis, limiting observations to either pre or post-treatment stages. Now, a breakthrough nanosurgical tool, which is around 500 times thinner than a human hair, could offer unprecedented insights into cancer treatment resistance.

The high-tech double-barrel nanopipette, developed by scientists at the University of Leeds (West Yorkshire, UK), enables - for the first time - the observation of individual living cancer cells' responses to treatment over time. This tool is equipped with two nanoscopic needles that enable simultaneous injection and extraction from the same cell, thus broadening the scope of its application. The semi-automatic nature of the platform significantly enhances the speed of data collection, allowing for more efficient and accurate analysis of a larger number of individual cells than ever before.

The nanosurgical device can perform repeated biopsies on a living cell throughout cancer treatment. It samples small portions of the cell's contents without causing cell death, thereby letting scientists monitor the cell's reaction over a period. In their research focusing on GBM, the scientists used this tool to evaluate how cancer cells develop resistance to chemotherapy and radiotherapy. Due to its minuscule size, the nanopipette is operated through robotic software that precisely controls the tiny needles, maneuvering them into the cells in a petri dish. The second needle of the nanopipette is crucial in operating the device. This innovation allows scientists to take repeated samples, enabling them to track disease progression in individual cells, a feat previously unachievable with existing technologies.

“This is a significant breakthrough. It is the first time that we have a technology where we can actually monitor the changes taking place after treatment, rather than just assume them,” said Dr. Lucy Stead, Associate Professor of Brain Cancer Biology at the University of Leeds’ School of Medicine. “This type of technology is going to provide a layer of understanding that we have simply never had before. And that new understanding and insight will lead to new weapons in our armory against all types of cancer.”

Related Links:
University of Leeds

Gold Member
STI Test
Vivalytic Sexually Transmitted Infection (STI) Array
Gold Member
SARS‑CoV‑2/Flu A/Flu B/RSV Sample-To-Answer Test
SARS‑CoV‑2/Flu A/Flu B/RSV Cartridge (CE-IVD)
Silver Member
Compact 14-Day Uninterrupted Holter ECG
NR-314P
New
Vibrating Mesh Nebulizer
Aerogen Solo

Print article

Channels

Critical Care

view channel
Image: This study is significant as it addresses a treatment approach that has not been extensively studied before (Photo courtesy of 123RF)

Study Confirms Safety of DCB-Only Strategy for Treating De Novo Left Main Coronary Artery Disease

There has been a lack of extensive research on the use of drug-coated balloon (DCB)-only strategy for the treatment of de novo left main coronary artery disease, especially in high bleeding risk (HBR) patients.... Read more

Patient Care

view channel
Image: The newly-launched solution can transform operating room scheduling and boost utilization rates (Photo courtesy of Fujitsu)

Surgical Capacity Optimization Solution Helps Hospitals Boost OR Utilization

An innovative solution has the capability to transform surgical capacity utilization by targeting the root cause of surgical block time inefficiencies. Fujitsu Limited’s (Tokyo, Japan) Surgical Capacity... Read more

Health IT

view channel
Image: First ever institution-specific model provides significant performance advantage over current population-derived models (Photo courtesy of Mount Sinai)

Machine Learning Model Improves Mortality Risk Prediction for Cardiac Surgery Patients

Machine learning algorithms have been deployed to create predictive models in various medical fields, with some demonstrating improved outcomes compared to their standard-of-care counterparts.... Read more

Point of Care

view channel
Image: The Quantra Hemostasis System has received US FDA special 510(k) clearance for use with its Quantra QStat Cartridge (Photo courtesy of HemoSonics)

Critical Bleeding Management System to Help Hospitals Further Standardize Viscoelastic Testing

Surgical procedures are often accompanied by significant blood loss and the subsequent high likelihood of the need for allogeneic blood transfusions. These transfusions, while critical, are linked to various... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.