We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Sekisui Diagnostics UK Ltd.

Download Mobile App

Sprayable Gel to Make Minimally Invasive Surgeries Simpler and Safer

By HospiMedica International staff writers
Posted on 13 Mar 2024
Print article
Image: The new gel can be sprayed onto the surgical sites via catheter, through an endoscope (Photo courtesy of MIT)
Image: The new gel can be sprayed onto the surgical sites via catheter, through an endoscope (Photo courtesy of MIT)

Routine screenings for colon cancer frequently identify small precancerous polyps that can be excised before turning cancerous, typically via endoscopy. During polyp removal, if bleeding ensues, cauterization is a common method to stem the bleeding, though it leaves scars and may slow healing, leading to further complications. Complicating matters, some patients experience delayed bleeding days after the procedure, leading to hospital readmission for treatment. Additionally, the development of minor tears may cause intestinal content leakage into the abdomen, risking severe infection and necessitating emergency intervention. For tissue reinforcement, doctors sometimes employ metal clips, which are unsuitable for larger polyps and may fail. Previous attempts to create a sealing gel have been unsuccessful, mainly due to the inability of materials to adhere to the surgical site beyond a period of 24 hours.

Now, researchers at MIT (Cambridge, MA, USA) have developed a new gel named GastroShield that can be sprayed onto surgical sites using an endoscope. This gel forms a durable, yet flexible layer, acting as a protective barrier over the affected area, preventing delayed bleeding and reinforcing the mechanical integrity of the tissue. The team experimented with several material combinations in search of a formulation that could be easily delivered through an endoscope's catheter nozzle and rapidly transform into a sturdy gel upon contacting tissue. The selected formulation comprised a polymer known as pluronic, a block copolymer forming micelles with amine groups on their surface, and oxidized dextran, a polysaccharide forming strong, reversible bonds with pluronic's amine groups. This interaction instantaneously creates a solid gel upon application, capable of self-repair against forces generated by digestive movements and food passage.

The novel gel can withstand the digestive tract's acidity and enzymatic activity to protect the healing tissues from these aggressive conditions, thus holding the potential for other gastrointestinal wounds prone to bleeding like stomach ulcers. Animal testing demonstrated all subjects treated with GastroShield exhibited quick sealing without subsequent perforations, leakages, or bleeding over the following week. GastroShield integrates seamlessly with existing endoscopic techniques and provides up to a week of wound protection to facilitate post-surgery healing. The team conducted several biocompatibility assessments that confirmed the gel's safety without any adverse outcomes. Ongoing research aims to adapt the material for human application, with potential for use beyond colonoscopies to include stomach ulcer treatments, Crohn’s disease management, and potentially for delivering chemotherapy for cancer.

“A key feature of this new technology is our aim to make it translational. GastroShield was designed to be stored in liquid form in a ready-to-use kit. Additionally, it doesn’t require any activation, light, or trigger solution to form the gel, aiming to make endoscopic use easy and fast,” said Gonzalo Muñoz Taboada, CEO of BioDevek, who is currently leading the translational effort for GastroShield.

Related Links:

Gold Member
STI Test
Vivalytic Sexually Transmitted Infection (STI) Array
Gold Member
POC Blood Gas Analyzer
Stat Profile Prime Plus
Silver Member
Wireless Mobile ECG Recorder
Bilirubin Lamp

Print article


Critical Care

view channel
Image: This study is significant as it addresses a treatment approach that has not been extensively studied before (Photo courtesy of 123RF)

Study Confirms Safety of DCB-Only Strategy for Treating De Novo Left Main Coronary Artery Disease

There has been a lack of extensive research on the use of drug-coated balloon (DCB)-only strategy for the treatment of de novo left main coronary artery disease, especially in high bleeding risk (HBR) patients.... Read more

Patient Care

view channel
Image: The newly-launched solution can transform operating room scheduling and boost utilization rates (Photo courtesy of Fujitsu)

Surgical Capacity Optimization Solution Helps Hospitals Boost OR Utilization

An innovative solution has the capability to transform surgical capacity utilization by targeting the root cause of surgical block time inefficiencies. Fujitsu Limited’s (Tokyo, Japan) Surgical Capacity... Read more

Health IT

view channel
Image: First ever institution-specific model provides significant performance advantage over current population-derived models (Photo courtesy of Mount Sinai)

Machine Learning Model Improves Mortality Risk Prediction for Cardiac Surgery Patients

Machine learning algorithms have been deployed to create predictive models in various medical fields, with some demonstrating improved outcomes compared to their standard-of-care counterparts.... Read more

Point of Care

view channel
Image: The Quantra Hemostasis System has received US FDA special 510(k) clearance for use with its Quantra QStat Cartridge (Photo courtesy of HemoSonics)

Critical Bleeding Management System to Help Hospitals Further Standardize Viscoelastic Testing

Surgical procedures are often accompanied by significant blood loss and the subsequent high likelihood of the need for allogeneic blood transfusions. These transfusions, while critical, are linked to various... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.