We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Sekisui Diagnostics UK Ltd.

Download Mobile App




New Method for Triggering and Imaging Seizures to Help Guide Epilepsy Surgery

By HospiMedica International staff writers
Posted on 13 Mar 2024
Print article
Image: Overview of the seizure triggering electrodes and the brain reconstruction method (Photo courtesy of University Hospital of Bern)
Image: Overview of the seizure triggering electrodes and the brain reconstruction method (Photo courtesy of University Hospital of Bern)

Individuals experiencing epilepsy and seizures unmanageable with medication often find brain surgery beneficial. This procedure aims to excise the epileptic tissue while preserving healthy tissue, thus controlling seizures without inducing neurological damage. Accurately identifying the epileptic tissue is crucial for the success of such surgeries, and the acquisition of images during seizures can significantly enhance the precision of surgical planning. Traditionally, ictal SPECT has been the exclusive neuro-imaging technique capable of capturing seizures as they occur within the brain since the 1990s. Yet, the increasing demands on healthcare resources and time have led many epilepsy centers to forgo this informative method. A new approach for inducing and imaging seizures could now enable clinicians to obtain real-time insights for customizing epilepsy surgery more effectively.

In comparison to the previous approach, where physicians from neurology and nuclear medicine waited for hours to days to capture the onset of a seizure, the new method developed by researchers at University Hospital of Bern (Bern, Switzerland), is more convenient, requires fewer resources, and is clinically feasible. In their study involving three adult subjects with left temporal lobe epilepsy, the researchers decided not to wait for spontaneous occurrences and instead imaged planned seizures that were triggered with targeted electrical stimulation to the brain. The research team employed stereotactic electroencephalography (sEEG) leads placed in specific brain regions to induce seizures characteristic of each patient. A radiotracer, 99mTc-HMPAO, was administered within 12 seconds of the seizure's start, with SPECT imaging following within 40 minutes.

The method successfully triggered seizures in all the participants, replicating each patient's typical seizure presentation and electrographic pattern observed through sEEG, without causing any adverse effects. The seizures induced were specific for each patient, with early seizure spread being uniquely imaged. In the first two cases, ictal SPECT provided additional insights beyond those offered by sEEG, highlighting the early involvement of brain regions lacking electrode coverage. In the third case, both sEEG and ictal SPECT provided overlapping information.

“The finding of this study is of practical nature, as it greatly facilitates the acquisition of the ictal SPECT,” said Thomas Pyka, MD, Privatdozent in the Department of Nuclear Medicine at the University Hospital of Bern. “This may help obtain images of greater quality and could contribute to the refinement of resection planning, improving seizure and cognitive outcomes in epilepsy surgery.”

Related Links:
University Hospital of Bern

Gold Member
Real-Time Diagnostics Onscreen Viewer
GEMweb Live
Gold Member
Disposable Protective Suit For Medical Use
Disposable Protective Suit For Medical Use
Silver Member
Compact 14-Day Uninterrupted Holter ECG
NR-314P
New
Examination Table
Powerline Backrest Top

Print article

Channels

Critical Care

view channel
Image: This study is significant as it addresses a treatment approach that has not been extensively studied before (Photo courtesy of 123RF)

Study Confirms Safety of DCB-Only Strategy for Treating De Novo Left Main Coronary Artery Disease

There has been a lack of extensive research on the use of drug-coated balloon (DCB)-only strategy for the treatment of de novo left main coronary artery disease, especially in high bleeding risk (HBR) patients.... Read more

Patient Care

view channel
Image: The newly-launched solution can transform operating room scheduling and boost utilization rates (Photo courtesy of Fujitsu)

Surgical Capacity Optimization Solution Helps Hospitals Boost OR Utilization

An innovative solution has the capability to transform surgical capacity utilization by targeting the root cause of surgical block time inefficiencies. Fujitsu Limited’s (Tokyo, Japan) Surgical Capacity... Read more

Health IT

view channel
Image: First ever institution-specific model provides significant performance advantage over current population-derived models (Photo courtesy of Mount Sinai)

Machine Learning Model Improves Mortality Risk Prediction for Cardiac Surgery Patients

Machine learning algorithms have been deployed to create predictive models in various medical fields, with some demonstrating improved outcomes compared to their standard-of-care counterparts.... Read more

Point of Care

view channel
Image: The Quantra Hemostasis System has received US FDA special 510(k) clearance for use with its Quantra QStat Cartridge (Photo courtesy of HemoSonics)

Critical Bleeding Management System to Help Hospitals Further Standardize Viscoelastic Testing

Surgical procedures are often accompanied by significant blood loss and the subsequent high likelihood of the need for allogeneic blood transfusions. These transfusions, while critical, are linked to various... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.