We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Detecto

Download Mobile App




Events

ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.
09 Dec 2022 - 11 Dec 2022

New Material Aids Facial Skin Reconstruction

By HospiMedica International staff writers
Posted on 11 Aug 2011
Print article
An injectable composite of biological and synthetic molecules shows promise in restoring damaged soft tissue relatively safely and durably.

Researchers at Johns Hopkins University (Baltimore, MD, USA) created the new composite material from hyaluronic acid (HA), a natural component in skin of young people that confers elasticity, and polyethylene glycol (PEG), a synthetic molecule used successfully as surgical glue in operations and known not to cause severe immune reactions. The PEG can be cross-linked-- forming sturdy chemical bonds between many individual molecules--using energy from light, which traps the HA molecules with it. Such cross-linking makes the implant hold its shape and not dissipate away from the injection site.

To develop the best PEG-HA composite with the highest long-term stability, the researchers injected different concentrations of PEG and HA under the skin and into the back muscle of rats, used a green light emitting diode (LED) light to gel the material, and then used magnetic resonance imaging (MRI) to monitor the persistence of the implant over time. The MRIs and direct measurements of the implants showed that the ones created from HA and the highest tested concentration of PEG with HA remained the same size over time, compared to injections of only HA, which shrank over time.

The researchers also evaluated the safety and persistence of the PEG-HA implants in three volunteers undergoing abdominoplasty. Technicians injected about five drops of PEG-HA or HA alone under the belly skin. The participants said they sensed heat and pain during the gel setting process; 12 weeks after implantation, MRI revealed no loss of implant size in patients. Removal of the implants and inspection of the surrounding tissue revealed mild to moderate inflammation, a response similar to that seen in the rats, although the types of white blood cells (WBCs) responding to implant differed between the rodents and humans. The difference was attributed to the fact that the target tissue in the rats (muscle) was different than human belly fat. The study was published in the July 27, 2011, issue of Science Translational Medicine.

“Implanted biological materials can mimic the texture of soft tissue, but are usually broken down by the body too fast, while synthetic materials tend to be more permanent but can be rejected by the immune system and typically don’t meld well with surrounding natural tissue,” said lead author Prof. Jennifer Elisseeff, MD, PhD, director of the Translational Tissue Engineering Center at JHU School of Medicine. “Our composite material has the best of both worlds, with the biological component enhancing compatibility with the body and the synthetic component contributing to durability.”

“Many of the skin fillers available on the market consisting of HA-like materials used for face lifts are only temporarily effective, and are limited in their ability to resculpt entire areas of the face,” added Professor Elisseeff. “Our hope is to develop a more effective product for people, like our war veterans, who need extensive facial reconstruction.”

Related Links:

Johns Hopkins University

BMP Whole Blood Analyzer: GEM Premier ChemSTAT
New
Gold Supplier
Chemiluminescence Immunoassay Analyzer
MAGICL 6000
New
Automated Nucleic Acid Extraction Instrument
DA3500
New
Silver Supplier
Urinalysis Dipstick Control
Dipper Urinalysis Dipstick Control

Print article
Radcal

Channels

AI

view channel
Image: AI transforms smartwatch ECG signals into a diagnostic tool for heart failure (Photo courtesy of Pexels)

AI-Based Smartwatch Accurately Detects Heart Failure Using ECG Signals

People with a weak heart pump might not have symptoms, but this common form of heart disease affects about 2% of the population and 9% of people over 60. When the heart cannot pump enough oxygen-rich blood,... Read more

Critical Care

view channel
Image: Quantra Hemostasis Analyzer (Photo courtesy of HemoSonics)

Next-Gen POC Whole Blood Hemostasis System Recognizes Specific Needs of EDs and ORs

Current hemostatic tests provide only a subset of needed information, or take too long to be useful in critical bleeding situations, forcing clinicians to use iterative transfusion protocols that do not... Read more

Patient Care

view channel
Image: Automated cleaning system allows endoscopes to be cleaned direct from clinic (Photo courtesy of Aston University)

World’s First Automated Endoscope Cleaner Fights Antimicrobial Resistance

Endoscopes are long, thin tubes with a light and camera at one end. Due to the sensitivity of the materials and electronics they cannot be sterilized in an autoclave (a machine that uses steam under pressure),... Read more

Health IT

view channel
Image: Using digital data can improve health outcomes (Photo courtesy of Unsplash)

Electronic Health Records May Be Key to Improving Patient Care, Study Finds

When a patient gets transferred from a hospital to a nearby specialist or rehabilitation facility, it is often difficult for personnel at the new facility to access the patient’s electronic health records... Read more

Business

view channel
Image: The global multiparameter patient monitoring systems market is expected to surpass USD 15 billion by 2028 (Photo courtesy of Unsplash)

Global Multiparameter Patient Monitoring Systems Market Driven by Rising Chronic Illnesses

Multi-parameter patient monitoring equipment is used to assess the vital signs of patients who are suffering from a serious illness. These devices are meant to give the number of data sets on one screen... Read more
Copyright © 2000-2022 Globetech Media. All rights reserved.