We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Detecto

Download Mobile App




Events

ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.
16 Feb 2023 - 18 Feb 2023

3D-Printing Technique Fabricates Microphysiological Devices

By HospiMedica International staff writers
Posted on 09 Nov 2016
Print article
Image: Close up of 3D printer printing heart-on-a-chip MPD (Photo courtesy of Harvard University).
Image: Close up of 3D printer printing heart-on-a-chip MPD (Photo courtesy of Harvard University).
Multi-material three-dimensional (3D) printing may one day be used to design organs-on-chips that match the properties of a specific disease, or even an individual patient’s cells.

Researchers at Harvard University (Cambridge, MA, USA) have developed a new technique to fabricate instrumented cardiac microphysiological devices (MPDs) that uses a mix of six functional inks that are based on piezo-resistive, high-conductance, biocompatible soft materials. By using 3D printing, the researchers were able to print a physio-mimetic, laminar cardiac tissue MPD that integrates soft strain sensors into the micro-architecture of the tissue, all in a single, continuous procedure.

The chip contains multiple wells, each with separate tissues and integrated sensors, which allows the researchers to study many engineered cardiac tissues at once. To demonstrate the efficacy of the device, the researchers first validated that the embedded sensors provided non-invasive, electronic readouts of tissue contractile stresses inside cell incubator environments. They then used the MPD to study drug responses, as well as the contractile development of human stem cell-derived laminar cardiac tissues over four weeks. The study was published on October 24, 2016, in Nature Materials.

“Researchers are often left working in the dark when it comes to gradual changes that occur during cardiac tissue development and maturation, because there has been a lack of easy, non-invasive ways to measure the tissue functional performance,” said lead author Johan Ulrik Lind, PhD. “These integrated sensors allow researchers to continuously collect data while tissues mature and improve their contractility. Similarly, they will enable studies of gradual effects of chronic exposure to toxins.”

“Our microfabrication approach opens new avenues for in vitro tissue engineering, toxicology, and drug screening research,” said study co-author professor of bioengineering and applied physics Kit Parker, PhD. “Translating microphysiological devices into truly valuable platforms for studying human health and disease requires that we address both data acquisition and manufacturing of our devices. This work offers new potential solutions to both of these central challenges.”

MPDs, also known as organs-on-chips, mimic the structure and function of native tissue in-vitro and have emerged as a promising alternative to traditional animal testing; but the fabrication and data collection process is expensive and laborious. Currently, these devices are built in clean rooms using a complex, multi-step lithographic process, and collecting data requires microscopy or high-speed cameras, since they do not have integrated sensors.

Related Links:
Harvard University

Gold Supplier
12-Channel ECG
CM1200B
New
Surgical Table
ARCUS 601
New
Ultrasound System
HERA W10 Elite
New
High Frequency X-Ray Generator
SHFR

Print article

Channels

AI

view channel
Image: A novel research study moves the needle on predicting coronary artery disease (Photo courtesy of Pexels)

AI-Enabled ECG Analysis Predicts Heart Attack Risk Nearly as well as CT Scans

Increased coronary artery calcium is a marker of coronary artery disease that can lead to a heart attack. Traditionally, CT scans are used to diagnose buildup of coronary artery calcium, although CT scanners... Read more

Critical Care

view channel
Image: The new biomaterial heals tissues from the inside out (Photo courtesy of UC San Diego)

Groundbreaking Biomaterial Injected Intravenously Repairs Cells and Tissue Damaged by Heart Attack and TBI

Following a heart attack, there is development of scar tissue, which affects muscle function and can result in congestive heart failure. However, there is still no established treatment available for repairing... Read more

Surgical Techniques

view channel
Image: The neuro-chip with soft implantable electrodes could manage brain disorders (Photo courtesy of EPFL)

Implantable Neuro-Chip Uses Machine Learning Algorithm to Detect and Treat Neurological Disorders

Using a combination of low-power chip design, machine learning algorithms, and soft implantable electrodes, researchers have produced a neural interface that can identify and suppress symptoms of different... Read more

Point of Care

view channel
Image: Steripath improves the diagnostic accuracy and timeliness of sepsis test results (Photo courtesy of Magnolia)

All-in-One Device Reduces False-Positive Diagnostic Test Results for Bloodstream Infections

Blood cultures are considered the gold standard diagnostic test for the detection of blood stream infections, such as sepsis. However, positive blood culture results can be frequently wrong, and about... Read more

Business

view channel
Image: The global patient positioning systems market is projected to reach USD 1.7 billion by 2027 (Photo courtesy of Pexels)

Global Patient Positioning Systems Market Driven by Increasing Chronic Diseases

The global patient positioning systems market is projected to grow at a CAGR of 4% from USD 1.4 billion in 2022 to USD 1.7 billion by 2027, driven by increasing technological advancements in medical devices,... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.