We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App




Colorimetric Bandages Identify and Treat Bacterial Infections

By HospiMedica International staff writers
Posted on 10 Feb 2020
Print article
Image: A color-changing bandage treats infections (Photo courtesy of CAS)
Image: A color-changing bandage treats infections (Photo courtesy of CAS)
Innovative color-changing bandages can sense drug-resistant and drug-sensitive bacteria in wounds and treat them accordingly, claims a new study.

Developed at the Chinese Academy of Sciences (CAS; Shenyang, China) and the University of Science and Technology of China (USTC; Hefei, China), the new paper-based bandaid (PBB) visually implements a selective antibacterial strategy. The PBB changes color from green to yellow when it contacts the acidic microenvironment of a bacterial infection; if drug-resistant bacteria are present, the bandage turns red in color through the action of an enzyme produced by the resistant microbes.

If an infection is detected, the PBB releases an antibiotic that kills drug-sensitive bacteria. When drug resistant bacteria are detected, Zr-MOF PCN-224-based photodynamic therapy (PDT) is used on the wound site to treat the resistant strains by releasing reactive oxygen species (ROS) that kill or weaken the bacteria, making them more susceptible to the antibiotic. The limit of detection is 104 CFU/mL for drug-resistant E. coli. The study was published on January 29, 2020, in ACS Central Science.

“Compared with traditional PDT-based antibacterial strategies, our design can alleviate off-target side effects, maximize therapeutic efficacy, and track the drug resistance in real time with the naked eye,” concluded senior author Xiaogang Qu, PhD, of the CAS Changchun Institute of Applied Chemistry, and colleagues. “This work develops a new way for the rational use of antibiotics. Given the low cost and easy operation of this point-of-care device, it can be developed for practical applications.”

PDT is used clinically to treat a wide range of medical conditions, including wet age-related macular degeneration and malignant cancers, and is recognized as a treatment strategy which is both minimally invasive and minimally toxic. While the applicability and potential of PDT has been known for over a hundred years, the development of modern PDT has been a gradual one, involving scientific progress in the fields of photobiology and cancer biology, as well as the development of modern photonic devices, such as lasers and light emitting diodes (LEDs).

Related Links:
Chinese Academy of Sciences
University of Science and Technology of China


Gold Member
POC Blood Gas Analyzer
Stat Profile Prime Plus
Gold Member
STI Test
Vivalytic Sexually Transmitted Infection (STI) Array
Silver Member
Compact 14-Day Uninterrupted Holter ECG
NR-314P
New
Examination Table
Powerline Backrest Top

Print article

Channels

Surgical Techniques

view channel
Image: NTT and Olympus have begun the world\'s first joint demonstration experiment of a cloud endoscopy system (Photo courtesy of Olympus)

Cloud Endoscopy System Enables Real-Time Image Processing on the Cloud

Endoscopes, which are flexible tubes inserted into the body's natural openings for internal examination and biopsy collection, are becoming increasingly vital in medical diagnostics. Their minimal invasiveness... Read more

Patient Care

view channel
Image: The newly-launched solution can transform operating room scheduling and boost utilization rates (Photo courtesy of Fujitsu)

Surgical Capacity Optimization Solution Helps Hospitals Boost OR Utilization

An innovative solution has the capability to transform surgical capacity utilization by targeting the root cause of surgical block time inefficiencies. Fujitsu Limited’s (Tokyo, Japan) Surgical Capacity... Read more

Health IT

view channel
Image: First ever institution-specific model provides significant performance advantage over current population-derived models (Photo courtesy of Mount Sinai)

Machine Learning Model Improves Mortality Risk Prediction for Cardiac Surgery Patients

Machine learning algorithms have been deployed to create predictive models in various medical fields, with some demonstrating improved outcomes compared to their standard-of-care counterparts.... Read more

Point of Care

view channel
Image: The PATHFAST hs-cTnI-II high-sensitivity troponin assay has been developed for the PATHFAST Biomarker Analyzer (Photo courtesy of Polymedco)

POC Myocardial Infarction Test Delivers Results in 17 Minutes

Chest pain is the second leading cause of emergency department (ED) visits by adults in the United States, generating over 7 million visits annually. In the event of a suspected heart attack, physicians... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.