We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Varian Medical Systems

Provides solutions for advancing cancer treatment, radiosurgery, X-ray imaging, & security, radiotherapy, radiosurger... read more Featured Products: More products

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

Microsphere Embolization Technology Treats Knee Osteoarthritis

By HospiMedica International staff writers
Posted on 26 Oct 2021
Print article
Image: Embozene microspheres are color-coded by size (Photo courtesy of Varian)
Image: Embozene microspheres are color-coded by size (Photo courtesy of Varian)
Novel microspheres can alleviate symptomatic knee osteoarthritis (OA) by reducing blood flow to the periarticular tissue of the joints, limiting the inflammatory process.

The Varian Medical Systems (Varian; Palo Alto, CA, USA) Embozene spheres are biocompatible hydrogel microspheres coated with a proprietary polymer (Polyzene-F). The minute spheres are color-coded by size to allow for easy identification, and are delivered pre-compressed to enable smooth delivery via catheter. Embozene microspheres are intended for embolization of arteriovenous malformations and hypervascular tumors, such as uterine fibroids and hepatoma, benign prostatic hyperplasia (BPH), and now for genicular artery embolization (GAE).

GAE is performed under moderate sedation as an outpatient procedure, generally taking one to two hours. The delivery catheter is inserted in a percutaneous procedure under fluoroscopic guidance, with the microspheres conveyed to arteries supplying the inflamed synovium (lining of the knee). By blocking the genicular arteries, there is a reduction in the amount of inflammation associated with OA, which can diminish or eliminate the associated knee pain. Embozene microspheres are packaged in 20 ml syringes, with an approximate 7 ml fill volume across the range.

“GAE holds great promise in providing clinicians with a new, non-invasive treatment option, which may not only ameliorate pain, but reduce the economic burden of this common disease,” said Frank Facchini, MD, president of Varian Interventional Solutions. “Varian's investigational program for GAE exemplifies our commitment to investing in our core technologies to determine their potential to treat the world's most debilitating diseases.”

“GAE is the first minimally invasive procedure that has demonstrated significant symptom improvement for a prolonged duration,” said Siddharth Padia, MD, director of interventional radiology at UCLA Santa Monica (CA, USA). “In a 40-patient, prospective study, the procedure resulted in a marked improvement in pain and function, and adverse events were uncommon and mild. I remain excited about the possibilities of this technology and its benefit to patients.”

OA is a group of abnormalities involving degradation of joints, including articular cartilage and subchondral bone. Symptoms may include joint pain, tenderness, stiffness, locking, and sometimes an effusion. A variety of causes--hereditary, developmental, metabolic, and mechanical deficits--may initiate processes leading to loss of cartilage. As a result of decreased movement secondary to pain, regional muscles may atrophy, and ligaments may become more lax. OA of the knee affects about 250 million people worldwide (3.6% of the population).

Related Links:
Varian Medical Systems

Gold Supplier
Temperature Monitor
ThermoScan Temperature Monitoring Unit
CFM Device
EEGDigiTrack CFM/aEEG Devices
Abdominal Stent Graft Platform
Ovation iX
Multi-Parameter Patient Monitor

Print article
FIME - Informa



view channel
Image: The AI tool can also tackle dangerous inequalities in heart attack diagnosis (Photo courtesy of Freepik)

AI Algorithm Integrates Cardiac Troponin Test Results with Clinical Data to Quickly Rule out Heart Attacks in Patients

The accepted standard for diagnosing myocardial infarction, or heart attack, involves assessing the blood for troponin levels. However, this approach applies the same benchmark for all patients, failing... Read more

Critical Care

view channel
Image: New technology gives patients the power to heal chronic wounds using their own blood (Photo courtesy of RedDress)

POC Solution Creates In Vitro Blood Clots from Patient’s Own Whole Blood in Real-Time to Treat Post-Surgical Wounds

Blood clots are a natural mechanism of the body's healing process. However, for chronic wounds resulting from diabetes and other conditions, blood is unable to reach these areas, hampering the initiation... Read more

Surgical Techniques

view channel
Image: The deployable electrodes are ideal for minimally invasive craniosurgery (Photo courtesy of EPFL)

Soft Robotic Electrode Offers Minimally Invasive Solution for Craniosurgery

Minimally invasive medical procedures offer numerous benefits to patients, including decreased tissue damage and shorter recovery periods. However, creating equipment that can pass through a small opening... Read more

Health IT

view channel
Image: First ever institution-specific model provides significant performance advantage over current population-derived models (Photo courtesy of Mount Sinai)

Machine Learning Model Improves Mortality Risk Prediction for Cardiac Surgery Patients

Machine learning algorithms have been deployed to create predictive models in various medical fields, with some demonstrating improved outcomes compared to their standard-of-care counterparts.... Read more

Point of Care

view channel
Image: IntelliSep is the first FDA-cleared diagnostic tool to assess cellular host response to aid in identifying ED patients with sepsis (Photo courtesy of Cytovale)

Rapid Microfluidic Test Demonstrates Efficacy as Diagnostic Aid to Improve Sepsis Triage in ED

Sepsis is the primary cause of mortality worldwide, accounting for over 350,000 fatalities annually in the United States alone, a figure that surpasses deaths from opioid overdoses, prostate cancer, and... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.