We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
GLOBETECH PUBLISHING LLC

Download Mobile App





Longer Interval Between COVID-19 Vaccines Generates Up to Nine Times as Many Antibodies

By HospiMedica International staff writers
Posted on 25 Apr 2022
Print article
Image: Longer interval between COVID-19 vaccines boosts antibody production (Photo courtesy of UKHSA)
Image: Longer interval between COVID-19 vaccines boosts antibody production (Photo courtesy of UKHSA)

Understanding the immune response to vaccination against COVID-19 is integral to controlling the virus and reducing the number of deaths. New research presented at this year’s European Congress of Clinical Microbiology & Infectious Diseases (ECCMID 2022) has shown that a longer interval between primary COVID-19 vaccine doses can boost antibody production up to nine-fold.

To find out factors affecting antibody responses following Pfizer/BioNTech COVID vaccination, researchers at the UK Health Security Agency (UKHSA, London, UK) measured antibody levels in blood samples taken from almost 6,000 healthcare workers from across the UK enrolled within the UK’s SIREN study (SARS-CoV-2 Infection and Reinfection and EvaluatioN). 3,989 of the 5,871 participants had their first dose of the vaccine at least 21 days earlier. 1,882 had their second dose at least 14 days earlier. The participants were classified by infection history as either previously having had COVID (confirmed by a PCR test or assumed due to their antibody profile) or naïve, with no history of infection. Almost all (>99%) of those who hadn’t had COVID seroconverted after vaccination, meaning they made antibodies against the virus.

Post-dose 1, those with previous infection had up to ten times higher antibody levels than naïve individuals, whilst after dose 2, those with previous infection had antibody levels more than twice as high as those who hadn’t had previous infection. When analyzing dosing intervals, it was found that longer dosing interval was associated with up antibody levels that were up to nine times higher in naïve participants (>2 and <4 weeks: 1,268.72 (1,043.25-1,542.91) and >10 weeks 11,479.73 (10,742.78-12,267.24), p=<0.0001) with a more pronounced effect observed in younger participants. Dosing interval didn’t affect antibody levels in those with previous infection. However, a longer interval between infection and vaccination was linked to higher antibody levels.

Those who had their first dose of the vaccine eight months after an infection had antibody levels seven times higher than those who were vaccinated three months after infection, with a plateau after eight months, suggesting that eight months after primary infection may be an optimum time to receive the first vaccine in those with prior infection. However, the analysis shows that regardless of timing between infection and vaccination, all individuals mount a very high antibody response after dose 2. In addition, female participants and those from an ethnic minority were associated with significantly higher antibody titers, whilst immunosuppression was associated with significantly lower post-vaccination antibody responses.

“This study shows that a longer time between vaccine dose 1 and dose 2 results in higher antibody responses in naïve participants, which strongly supports the decision by JCVI and the UK government to lengthen the interval between vaccine doses,” said Dr. Ashley Otter at the UKHSA. “We’ve also shown that in those with previous infection, timing between exposure and vaccination plays a critical role in post-vaccination antibody responses. However, further research is needed to determine whether these higher antibody levels provide greater protection against COVID-19 disease and how this longer dosing interval may affect booster responses.”

Related Links:
UKHSA

Platinum Supplier
Real-Time Diagnostics Onscreen Viewer
GEMweb Live
Gold Supplier
Enteral Feeding Pump
SENTINELplus
New
OT Light
LED 2 Smart
New
Non-Vented Full Face NIV Mask
F&P Visairo RT075

Print article
Radcal

Channels

Critical Care

view channel
Image: The new blood test could prevent some of the 350,000 sepsis deaths in the U.S. annually (Photo courtesy of Cytovale)

Sepsis Test Could Save Lives in Emergency Departments, Study Suggests

Sepsis poses a severe, life-endangering illness that arises when an infection triggers a body-wide chain reaction, potentially causing multiple organs to fail quickly. Prompt and accurate diagnosis is... Read more

Surgical Techniques

view channel
Image: Suppressing production of an immune protein could reduce rejection of biomedical implants (Photo courtesy of 123RF)

Protein Identified for Immune Rejection of Biomedical Implants to Pave Way for Bio-Integrative Medical Devices

Biomedical implants like breast implants, pacemakers, and orthopedic devices have revolutionized healthcare, yet a substantial number of these implants face rejection by the body and have to be removed.... Read more

Patient Care

view channel
Image: The newly-launched solution can transform operating room scheduling and boost utilization rates (Photo courtesy of Fujitsu)

Surgical Capacity Optimization Solution Helps Hospitals Boost OR Utilization

An innovative solution has the capability to transform surgical capacity utilization by targeting the root cause of surgical block time inefficiencies. Fujitsu Limited’s (Tokyo, Japan) Surgical Capacity... Read more

Health IT

view channel
Image: First ever institution-specific model provides significant performance advantage over current population-derived models (Photo courtesy of Mount Sinai)

Machine Learning Model Improves Mortality Risk Prediction for Cardiac Surgery Patients

Machine learning algorithms have been deployed to create predictive models in various medical fields, with some demonstrating improved outcomes compared to their standard-of-care counterparts.... Read more

Point of Care

view channel
Image: The broad-spectrum POC coagulometer is well-suited for emergency room and emergency vehicle use (Photo courtesy of Perosphere)

Novel POC Coagulometer with Lab-Like Precision to Revolutionize Coagulation Testing

In emergency settings, when patients arrive with a bleed or require urgent surgery, doctors rely solely on clinical judgment to determine if a patient is adequately anticoagulated for reversal treatment.... Read more

Business

view channel
Image: The global surgical lights market is expected to grow by close to USD 0.50 billion from 2022 to 2027 (Photo courtesy of Freepik)

Global Surgical Lights Market Driven by Increasing Number of Procedures

The global surgical lights market is set to witness high growth, largely due to the increasing incidence of chronic illnesses, a surge in demand for cosmetic and plastic surgeries, and untapped opportunities... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.