We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

United Imaging Healthcare

United Imaging develops and produces a full portfolio of advanced medical products covering the entire process of ima... read more Featured Products: More products

Download Mobile App





Total-Body PET Imaging Can Assess Immunological Response to COVID-19 Infections

By HospiMedica International staff writers
Posted on 12 Aug 2022
Print article
Image: uEXPLORER is the world`s first total-body PET/CT scanner (Photo courtesy of United Imaging Healthcare)
Image: uEXPLORER is the world`s first total-body PET/CT scanner (Photo courtesy of United Imaging Healthcare)

Cytotoxic T cells are key players in the cell-mediated immune response against viral infections. However, 95% of T cells are in tissues rather than in the blood circulation and are therefore difficult to assess non-invasively. Now, high sensitivity PET imaging using a specific T cell radiotracer offers a new methodology to track tissue concentrations of T cells without invasive sampling.

UC Davis (Davis, CA, USA) which collaborated with United Imaging Healthcare Co., Ltd. (Shanghai, China) to develop the world's first total-body PET/CT scanner, 'uEXPLORER presented their research on COVID-19 at the 2022 Society of Nuclear Medicine and Molecular Imaging (SNMMI) annual meeting. Guided by the uEXPLORER scanner along with a new labeled radiotracer with high affinity to T cells (89Zr-Crefmirlimab-Berdoxam), the scientists unveiled the first high-resolution PET image of total-body CD8+ T-cell distribution after COVID-19 infection. The image could shed light on the pathological mechanism and immune response to COVID-19 infection. The radiotracer used, 89Zr-Crefmirlimab-Berdoxam, is an investigational tracer provided for the study by ImaginAb who is currently in Phase IIb testing to determine predictive performance.

In the reported study, patients recovering from COVID-19 infection received a low injection dose (~0.5 mCi) of 89Zr-labeled radiotracer that targeted CD8+ T cells and underwent a uEXPLORER PET/CT scan at different time points. A control group was also studied. The total-body PET images revealed subtle differences between five recovering COVID-19 patients and three healthy volunteers. The exceptional image quality obtained using the uEXPLORER scanner confirmed CD8+ T cell deposition in the spleen, liver, bone marrow, lymph nodes, and tonsils, as well as differences in the clearance rate of the radiotracer from the blood. Imaging was accomplished with minimal radiation dose to the patients. This research paves the way for further exploration of the assessment of immune response to infectious diseases and cancer, the assessment of response to vaccines in human subjects, and the fundamental mechanisms of the immune system in general.

This disruptive technology co-developed by UC Davis and United Imaging pushes the boundaries of traditional PET scanners, with an effective sensitivity that is up to 68-fold greater than current commercial PET scanners. Combined with a 194 cm axial PET field of view, the uEXPLORER scanner can capture dynamic changes to radiotracer distribution across the entire human body with high temporal resolution, which is an essential attribute for this type of research.

“We have now contributed to several different disease areas based on the high sensitivity and total-body coverage of the uEXPLORER scanner,” said Simon R. Cherry, Ph.D., Distinguished Professor of Biomedical Engineering and Radiology at UC Davis “This research is another demonstration of how groundbreaking imaging technology, combined with highly specific radiotracers, can open new opportunities in studying the complex interactions within the whole body, both in health and in response to disease. We hope this research will contribute to a better understanding of the immunological response to COVID-19, and serve as an example for how the immune system can be interrogated at a systems level with total-body PET.”

Related Links:
UC Davis 
United Imaging Healthcare Co., Ltd. 

Gold Member
12-Channel ECG
CM1200B
Gold Member
Disposable Protective Suit For Medical Use
Disposable Protective Suit For Medical Use
Silver Member
Wireless Mobile ECG Recorder
NR-1207-3/NR-1207-E
New
Hospital Bed
Enterprise 9000X

Print article
Detecto

Channels

Critical Care

view channel
Image: Vascular flow modeling exemplar; intracranial aneurysm flow, treatment and thrombosis (Photo courtesy of University of Leeds)

Faster, More Accurate Blood Flow Simulation to Revolutionize Treatment of Vascular Diseases

The field of vascular flow modeling is vital for understanding and treating vascular diseases, but traditionally, these methods require extensive labor and computation. Now, researchers have made groundbreaking... Read more

Surgical Techniques

view channel
Image: The prototype pacemaker is made of a specially engineered membrane (Photo courtesy of University of Chicago)

Ultra-Thin, Light-Controlled Pacemaker Regulates Heartbeats

Millions of individuals depend on pacemakers, small yet vital devices that help maintain a regular heartbeat by regulating the heart's electrical impulses. To minimize complications, there is growing interest... Read more

Patient Care

view channel
Image: The newly-launched solution can transform operating room scheduling and boost utilization rates (Photo courtesy of Fujitsu)

Surgical Capacity Optimization Solution Helps Hospitals Boost OR Utilization

An innovative solution has the capability to transform surgical capacity utilization by targeting the root cause of surgical block time inefficiencies. Fujitsu Limited’s (Tokyo, Japan) Surgical Capacity... Read more

Health IT

view channel
Image: First ever institution-specific model provides significant performance advantage over current population-derived models (Photo courtesy of Mount Sinai)

Machine Learning Model Improves Mortality Risk Prediction for Cardiac Surgery Patients

Machine learning algorithms have been deployed to create predictive models in various medical fields, with some demonstrating improved outcomes compared to their standard-of-care counterparts.... Read more

Point of Care

view channel
Image: The new eye-safe laser technology can diagnose traumatic brain injury (Photo courtesy of 123RF)

Novel Diagnostic Hand-Held Device Detects Known Biomarkers for Traumatic Brain Injury

The growing need for prompt and efficient diagnosis of traumatic brain injury (TBI), a major cause of mortality globally, has spurred the development of innovative diagnostic technologies.... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.