Nanogel-Based Drug Delivery Technology to Improve UTI Treatment

Scientists from the University of Colorado Anschutz Medical Campus (Aurora, CO, USA) found that nanogel technology could deliver significantly more gentamicin than traditional methods, with a 36% higher concentration inside cells. Furthermore, this approach exhibited low toxicity, causing minimal harm to the cells. The nanogels also release the drug quickly, which enhances its ability to kill bacteria in the bladder faster. The researchers believe this innovative approach provides a more effective treatment by targeting infected cells directly, minimizing side effects, and reducing the risk of antibiotic resistance. They also suggest that this nanogel-based drug delivery system could be applied to other medical conditions beyond UTIs.

“We prove not only that this technology is doable but could be very effective for future clinical use and can potentially lead towards an eventual cure of recurrent infections,” said the paper’s senior author Michael Schurr, PhD, associate professor in the Department of Immunology & Microbiology at the University of Colorado School of Medicine.

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University of Colorado Anschutz Medical Campus