We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Agfa Radiology

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

Sepsis Therapeutic Device Cleans Infected Blood

By HospiMedica International staff writers
Posted on 07 Sep 2015
Print article
Image: The FcMBL blood-cleansing device (Photo courtesy of Wyss Institute at Harvard University).
Image: The FcMBL blood-cleansing device (Photo courtesy of Wyss Institute at Harvard University).
A novel blood-cleansing device based on a genetically engineered pathogen-capturing protein works by mimicking spleen function.

Developed by researchers at the Wyss Institute for Biologically Inspired Engineering (Boston, MA, USA), the sepsis device uses an innovative blood-cleansing approach that harnesses a proprietary pathogen-capturing agent called antibody Fc Mannose Binding Lectin (FcMBL), which binds all types of live and dead infectious microbes, including bacteria, fungi, viruses, and the endotoxins they release. As a universal device, it can be put into use quickly, even without identifying the infectious agent involved.

The concept is similar to that of a dialysis machine; infected blood is drawn from a vein through to the device, where FcMBL-coated magnetic beads are added to the blood. The pathogen-loaded beads are extracted by magnets within the device before the cleansed blood is returned to the body. The system uses commercial polysulfone or polyethersulfone cartridges coated with FcMBL. In animal studies the pathogen-extracting device reduced the number of E. coli, Staphylococcus aureus, and endotoxins circulating in the bloodstream by more than 99%. The device is described in the October 2015 of Biomaterials.

“The most effective strategy is to treat with the best antibiotics you can muster, while also removing the toxins and remaining pathogens from the patient's blood as quickly as possible,” said Donald Ingber, MD, PhD, founding director of the Wyss Institute. “Our goal is to see this move out of the lab and into hospitals as well as onto the battlefield, where it can save lives within years rather than decades.”

“If all goes well, physicians will someday be able to use the device in tandem with standard antibiotic treatments to deliver a one-two punch to pathogens, synergistically killing and cleansing all live and dead invaders from the bloodstream,” said lead author postdoctoral fellow Tohid Fatanat Didar, PhD. “Using the device, alone or alongside antibiotics, we can quickly bring blood back to normal conditions, curtailing an inflammatory response rather than exacerbating it.”

FcMBL is a genetically engineered blood protein inspired by a naturally-occurring human molecule called Mannose Binding Lectin (MBL), which is found in the innate immune system and binds to toxic invaders, marking them for capture by immune cells in the spleen.

Related Links:

Wyss Institute for Biologically Inspired Engineering

Print article
Clear Image Devices



view channel

IHF to Launch Geneva Centre of Healthcare Leadership for Sustainability

The International Hospital Federation (IHF; Geneva, Switzerland) is preparing to launch the Geneva Centre of Healthcare Leadership for Sustainability (the Centre) in 2022 in response to the need for hospitals... Read more
Copyright © 2000-2021 Globetech Media. All rights reserved.