Endovascular Treatment Effective with Carotid Disease

The MR CLEAN IAT protocol included intra-arterial thrombolysis, mechanical treatment, or both as treatment for acute ischemic stroke.

The primary measure was functional outcome, as measured by modified Rankin Scale at 90 days and reported as adjusted common odds ratio (acOR) for a shift in direction of a better outcome. The results showed that functional outcome was associated with an acOR of 1.67 in favor of the IAT intervention. In the analysis of the pre-specified subgroup of patients with ECD, acOR was 3.1, compared to an acOR of 1.3 in patients presenting without ECD. The study was published on May 23, 2017, in Annals of Internal Medicine.

“The presence of ECD is associated with less favorable clinical outcomes in patients with acute ischemic stroke caused by intracranial proximal occlusion, and acute IAT in the setting of extracranial and intracranial lesions is considered challenging,” concluded lead author Olvert Berkhemer, MD, PhD, of AMC, and colleagues. “IAT may be at least as effective in patients with ECD as in those without ECD, and it should not be withheld in these complex patients with acute ischemic stroke.”

Based on the Framingham Heart Study and Cardiovascular Health Study populations, the prevalence of ECD is approximately 9% in men and 6–7% in women, and it accounts for up to 15–20% of all ischemic strokes. Several possible mechanisms are involved, including atheroembolism of cholesterol crystals or other debris, artery-to-artery embolism of thrombus, dissection, acute thrombotic occlusion, and reduced cerebral perfusion with plaque growth.

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