We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Sekisui Diagnostics UK Ltd.

Download Mobile App





Machine Learning-Based Rapid Diagnostic Reads Immune System to Predict COVID-19 Severity Risk

By HospiMedica International staff writers
Posted on 30 Sep 2020
Print article
Image: Machine Learning-Based Rapid Diagnostic Reads Immune System to Predict COVID-19 Severity Risk (Photo courtesy of Inflammatix)
Image: Machine Learning-Based Rapid Diagnostic Reads Immune System to Predict COVID-19 Severity Risk (Photo courtesy of Inflammatix)
A rapid diagnostic that reads the immune system to predict severe respiratory failure risk in COVID-19 patients is being developed to help physicians make better hospital admission and resourcing decisions for COVID-19 patients at hospital presentation.

Inflammatix (Burlingame, CA, USA) has been awarded USD 1.1 million by the Defense Advanced Research Projects Agency (DARPA) for further development of the rapid diagnostic named CoVerity COVID-19 Severity Test. The Inflammatix approach – known as host-response diagnostics – rapidly reads the immune system using multiple mRNA biomarkers and a machine learning algorithm. The company is developing other host-response diagnostic tests that identify the presence and type of infection (viral or bacterial), in addition to predicting the risk of severe disease, to enable physicians to make more informed decisions for patients with acute infection and sepsis.

The company’s host-response diagnostic approach for predicting COVID-19 severity risk was shown to be superior to clinical biomarkers, including IL-6, in a new study presented recently at the 2020 European Society of Clinical Microbiology and Infection Diseases (ESCMID) Conference on Coronavirus Disease (ECCVID). In a prospective study of 97 patients with PCR-confirmed SARS-CoV-2 pneumonia and blood drawn on the day of hospital admission, CoVerity demonstrated an area under the receiver operating characteristic curve (AUROC) of 0.88 (95% CI 0.81-0.95) for identifying patients who developed respiratory failure or died, independent of age, while IL-6 had an AUROC of 0.73 (95% CI 0.62 - 0.85). The new classifier had the highest accuracy among all single biomarkers tested, including IL-6, procalcitonin, C-reactive protein, lactate, and SuPAR.

“While major progress has been made in developing rapid platforms to diagnose SARS-CoV-2 infection, predicting severity in COVID-19 patients remains an unmet medical need,” said Evangelos J. Giamarellos-Bourboulis, MD, Professor of Internal Medicine and Infectious Diseases at ATTIKON University General Hospital in Athens, Greece, Chairman of the European Sepsis Alliance, President of the European Shock Society, and lead investigator for the study. “In this study, the host-response approach demonstrated very high accuracy for identifying severe disease in COVID-19 patients and outperformed clinical markers for risk stratification. Existing tools have shown limited accuracy in enabling us to confidently identify high-risk patients early who need close monitoring or discharge non-severe patients to recover at home.”

“We are grateful that DARPA has recognized the promise of our host-response approach to benefit COVID-19 patients and caregivers, and we look forward to accelerating development and availability of our CoVerity COVID-19 Severity Test as a result of this agreement,” said Inflammatix CEO and Cofounder Tim Sweeney, MD, PhD. “The 5-mRNA classifier for CoVerity was developed on a training set of more than 20 clinical studies and we intend to translate it into a rapid assay that can be used as a clinical tool to help triage patients after diagnosis with COVID-19. Improved triage has the potential to reduce morbidity and mortality while enabling hospitals to allocate resources more effectively.”

Related Links:
Inflammatix

Gold Member
STI Test
Vivalytic Sexually Transmitted Infection (STI) Array
Gold Member
12-Channel ECG
CM1200B
Silver Member
Wireless Mobile ECG Recorder
NR-1207-3/NR-1207-E
New
Electrosurgical Unit
ARC 303

Print article

Channels

Surgical Techniques

view channel
Image: New studies suggest benefit of total robotic metabolic and bariatric surgery over conventional laparoscopy (Photo courtesy of 123RF)

Total Robotic Metabolic and Bariatric Surgery Proves More Beneficial than Conventional Laparoscopy

According to the U.S. Centers for Disease Control and Prevention (CDC), 42.4% of Americans are affected by obesity. Research indicates that obesity can compromise the immune system, trigger chronic inflammation,... Read more

Patient Care

view channel
Image: The portable, handheld BeamClean technology inactivates pathogens on commonly touched surfaces in seconds (Photo courtesy of Freestyle Partners)

First-Of-Its-Kind Portable Germicidal Light Technology Disinfects High-Touch Clinical Surfaces in Seconds

Reducing healthcare-acquired infections (HAIs) remains a pressing issue within global healthcare systems. In the United States alone, 1.7 million patients contract HAIs annually, leading to approximately... Read more

Health IT

view channel
Image: First ever institution-specific model provides significant performance advantage over current population-derived models (Photo courtesy of Mount Sinai)

Machine Learning Model Improves Mortality Risk Prediction for Cardiac Surgery Patients

Machine learning algorithms have been deployed to create predictive models in various medical fields, with some demonstrating improved outcomes compared to their standard-of-care counterparts.... Read more

Point of Care

view channel
Image: POCT offers cost-effective, accessible, and immediate diagnostic solutions (Photo courtesy of Flinders University)

POCT for Infectious Diseases Delivers Laboratory Equivalent Pathology Results

On-site pathology tests for infectious diseases in rural and remote locations can achieve the same level of reliability and accuracy as those conducted in hospital laboratories, a recent study suggests.... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.