We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Sekisui Diagnostics UK Ltd.

Download Mobile App

Novel Concept of Immunologic Resilience Can Accurately Predict Which COVID-19 Patients Will Advance to Severe Disease

By HospiMedica International staff writers
Posted on 09 Sep 2021
Print article
A novel concept called “immunologic resilience” can accurately predict which COVID-19 patients will advance to severe disease and which will not.

Researchers from UT Health San Antonio (San Antonio, TX, USA) and the South Texas Veterans Health Care System (San Antonio, TX, USA) who developed the concept define immunologic resilience as the capacity to preserve or restore immune competence and control inflammation in the face of infection or other antigenic challenges. This capacity does not depend solely on age, according to the researchers. In fact, the level of immunologic resilience that precedes COVID-19 and develops during the viral disease is a strong predictor of COVID-19 outcomes regardless of age.

An 18-year-old could have inferior immunologic resilience, resulting in a high risk of severe COVID-19, whereas an 80-year-old with robust resilience could manifest less severe COVID-19. However, with age, the proportion of individuals with capacity to preserve immunologic resilience declines, contributing to the greater burden of COVID-19 in older persons. Conceivably, durability of vaccines may wane in persons with inferior immunologic resilience, say the researchers.

The scientists developed novel metrics to monitor immunologic resilience and evaluated them in 522 COVID-19 patients. Each patient’s level of immunological resilience was assessed on the day of admission and then daily for varying durations. Patients whose infections did not require hospital admission were visited at home for assessments. For comparative purposes, the researchers evaluated metrics of immunologic resilience in 13,461 individuals without COVID-19.

The researchers quantified immunologic resilience through “immune health grades,” which are based on measures of infection-fighting T cells, and blood cell gene expression signatures. An immune health grade of I signifies the best immunity and a grade of IV the worst. The group also analyzed grades from large control groups of otherwise healthy adults. The immune health grades and overall concept of immunologic resilience accurately predicted most patient outcomes, which in addition to mortality included hospitalization, need for advanced respiratory support, and levels of SARS-CoV-2 in the nasopharynx. Those who entered the hospital with the best immune health grades had shorter stays and non-progressive COVID-19, findings showed.

“We applied these immune metrics to every COVID-19 patient who came into the VA hospital. These metrics are highly prognostic. Metrics tracking inferior immunologic resilience predicted up to 19-times higher risk of dying within 30 days, which was the primary outcome of the study,” said the first author of the study, Grace C. Lee, PharmD, PhD, assistant professor, UT Health Science Center San Antonio and The University of Texas at Austin College of Pharmacy, and senior translational research scientist with the Foundation for Advancing Veterans’ Health Research. “Remarkably, irrespective of their COVID-19 status, men have inferior immunologic resilience, which may explain why they are predisposed to worse COVID-19 outcomes.”

“The concept is a useful way to assess the severity levels of patients and understand their potential rate of progression and need for advanced therapies and longer hospitalizations,” said co-author Sandra Sanchez-Reilly, MD, professor of medicine at the health science center and associate chief of service for geriatrics and extended care in the South Texas Veterans Health Care System.

Related Links:
UT Health San Antonio
South Texas Veterans Health Care System

Gold Member
STI Test
Vivalytic Sexually Transmitted Infection (STI) Array
Gold Member
Solid State Kv/Dose Multi-Sensor
Silver Member
Wireless Mobile ECG Recorder
Mobile Digital X-Ray System

Print article


Surgical Techniques

view channel
Image: Concept of the wirelessly actuated undulating pump and its integration into an esophageal stent (Photo courtesy of Advanced Functional Materials/ doi.org/10.1002/adfm.202405865)

Wirelessly Activated Robotic Device Aids Digestion in Patients with Compromised Organs

The transport of fluids and solids is essential in the human body, driven by a wave-like movement in the lumen known as peristalsis. However, peristalsis can be disrupted in patients who have obstructions... Read more

Patient Care

view channel
Image: The portable, handheld BeamClean technology inactivates pathogens on commonly touched surfaces in seconds (Photo courtesy of Freestyle Partners)

First-Of-Its-Kind Portable Germicidal Light Technology Disinfects High-Touch Clinical Surfaces in Seconds

Reducing healthcare-acquired infections (HAIs) remains a pressing issue within global healthcare systems. In the United States alone, 1.7 million patients contract HAIs annually, leading to approximately... Read more

Health IT

view channel
Image: First ever institution-specific model provides significant performance advantage over current population-derived models (Photo courtesy of Mount Sinai)

Machine Learning Model Improves Mortality Risk Prediction for Cardiac Surgery Patients

Machine learning algorithms have been deployed to create predictive models in various medical fields, with some demonstrating improved outcomes compared to their standard-of-care counterparts.... Read more

Point of Care

view channel
Image: POCT offers cost-effective, accessible, and immediate diagnostic solutions (Photo courtesy of Flinders University)

POCT for Infectious Diseases Delivers Laboratory Equivalent Pathology Results

On-site pathology tests for infectious diseases in rural and remote locations can achieve the same level of reliability and accuracy as those conducted in hospital laboratories, a recent study suggests.... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.