We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Detecto

Download Mobile App




Events

ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.
16 Feb 2023 - 18 Feb 2023

MR-Guided Focused Ultrasound Controls Prostate Cancer with Fewer Side Effects

By HospiMedica International staff writers
Posted on 16 Jun 2022
Print article
Image: High-intensity focused ultrasound (HIFU) can control prostate cancer with fewer side effects (Photo courtesy of Pexels)
Image: High-intensity focused ultrasound (HIFU) can control prostate cancer with fewer side effects (Photo courtesy of Pexels)

When the cancer is confined to the prostate gland, the main treatment options have traditionally included active surveillance (close monitoring), surgery, and radiation. But men who needed surgery or radiation often had persistent side effects, such as urinary and sexual problems, that could reduce quality of life. In recent years, a new treatment strategy known as focal therapy (partial gland ablation) has emerged for prostate cancer considered to be “intermediate risk” - mostly, small tumors confined to one area of the prostate. Now, a landmark clinical trial has demonstrated that an advanced focal therapy approach and less-invasive method known as high-intensity focused ultrasound (HIFU), guided by magnetic resonance imaging (MRI), works well for many patients.

Results from the clinical trial conducted by researchers at Memorial Sloan Kettering Cancer Center (MSK, New York, NY, USA) represent a major step toward having the new HIFU approach become part of widespread prostate cancer treatment. The phase 2 trial looked at a particular type of HIFU treatment, also called MR-guided focused ultrasound (MRgFUS), in men with intermediate-risk cancer. The novel approach effectively controlled the disease in patients and greatly reduced adverse side effects of treatment. This suggests many men with intermediate-risk prostate cancer can avoid surgery, chemotherapy, and radiation.

MRgFUS is an outpatient treatment that takes about two hours. Patients under anesthesia are placed in an MRI machine that covers the lower half of the body. After the machine takes an image of the prostate, the doctors outline the treatment area and deliver the focused ultrasound waves, guided by the MRI. The ultrasound waves come from different directions, intersecting to attack and kill the cancer by heating the cells to more than 158 °F (70 °C).

In the phase 2 clinical trial, 101 men received the novel MRgFUS treatment and then were biopsied six months and 24 months later. There was no intermediate- or higher-risk cancer left in the treated area for 88% of the patients. Based on this data, the FDA in December 2021 granted approval for the technology, called Exablate Prostate, to treat prostate tissue. The FDA also approved an investigator-initiated trial to compare MRgFUS focal therapy to active surveillance and demonstrate a clinical benefit for patients with prostate cancer. Using MRgFUS for intermediate-risk cancers has become possible due to two important developments over the past 15 years. First, there was an acceptance by experts of using active surveillance for low-grade tumors. The second advance was new imaging technology that enabled MRIs to be incorporated into ultrasound treatment.

“We believe this novel treatment strategy will improve the lives of many prostate cancer patients,” said MSK urologic cancer surgeon Behfar Ehdaie who led the phase 2 trial. “To draw a parallel with how breast cancer treatment changed 30 years ago, you could think of focal therapy as a ‘male lumpectomy.’ Instead of removing all the tissue in a breast or prostate, we have learned that it is safe and effective to treat specific areas and greatly reduce the burden on patients.”

“Advancements in prostate cancer over the past two decades have been headlined by successes that have benefited all patients, and now focal therapy provides another exciting area that can move the needle in prostate cancer management,” Dr. Ehdaie added.

Related Links:
MSK 

New
Platinum Supplier
Real-Time Diagnostics Onscreen Viewer
GEMweb Live
New
Ceiling-Mounted Digital X-Ray System
DigitalDiagnost C50
New
X-Ray Image Acquisition Software
dicomPACS DX-R
New
Blood Warmer
SAHARA-III 230 V

Print article

Channels

AI

view channel
Image: A novel research study moves the needle on predicting coronary artery disease (Photo courtesy of Pexels)

AI-Enabled ECG Analysis Predicts Heart Attack Risk Nearly as well as CT Scans

Increased coronary artery calcium is a marker of coronary artery disease that can lead to a heart attack. Traditionally, CT scans are used to diagnose buildup of coronary artery calcium, although CT scanners... Read more

Surgical Techniques

view channel
Image: The neuro-chip with soft implantable electrodes could manage brain disorders (Photo courtesy of EPFL)

Implantable Neuro-Chip Uses Machine Learning Algorithm to Detect and Treat Neurological Disorders

Using a combination of low-power chip design, machine learning algorithms, and soft implantable electrodes, researchers have produced a neural interface that can identify and suppress symptoms of different... Read more

Health IT

view channel
Image: Using digital data can improve health outcomes (Photo courtesy of Unsplash)

Electronic Health Records May Be Key to Improving Patient Care, Study Finds

When a patient gets transferred from a hospital to a nearby specialist or rehabilitation facility, it is often difficult for personnel at the new facility to access the patient’s electronic health records... Read more

Point of Care

view channel
Image: Steripath improves the diagnostic accuracy and timeliness of sepsis test results (Photo courtesy of Magnolia)

All-in-One Device Reduces False-Positive Diagnostic Test Results for Bloodstream Infections

Blood cultures are considered the gold standard diagnostic test for the detection of blood stream infections, such as sepsis. However, positive blood culture results can be frequently wrong, and about... Read more

Business

view channel
Image: Researchers expect broader adoption of AI in healthcare in the near future (Photo courtesy of Pexels)

Artificial Intelligence (AI) Could Save U.S. Healthcare Industry USD 360 Billion Annually

The wider adoption of artificial intelligence (AI) in healthcare could save the U.S. up to USD 360 billion annually although its uptake in the industry is presently limited owing to the absence of trust... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.