We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Detecto

Download Mobile App





Study Reveals New Imaging Findings in Patients with Breakthrough COVID-19 Infections

By HospiMedica International staff writers
Posted on 17 Dec 2021
Print article
Illustration
Illustration

A new study has found that the majority of patients with breakthrough COVID-19 illness had absent or mild imaging findings and a benign clinical course.

The study by researchers at the University of Maryland School of Medicine (Baltimore, MD, USA) aimed to characterize chest radiograph and CT imaging appearance in patients with breakthrough COVID-19 (defined as an illness occurring in patients that previously received a COVID-19 vaccination) in a hospital setting.

Despite the demonstrated effectiveness of the COVID-19 directed vaccines, notably messenger RNA vaccines, a proportion of fully vaccinated individuals still develop COVID-19 illness. These infections are being reported as “breakthrough” cases. It is well recognized that no vaccine is 100% effective and thus breakthrough illness in some individuals is expected. Patients who develop such COVID-19 breakthrough illness may be asymptomatic or symptomatic requiring outpatient or inpatient treatment, rarely leading to death. As the protective effects of the vaccine wane and new variants arise, the number of breakthrough cases will likely increase. While the clinical aspects of COVID-19 breakthrough have been described, there has been minimal attention devoted to its imaging manifestations.

In the new study, researchers reported the chest imaging findings in a series of individuals with breakthrough COVID-19 who required hospitalization. The study involved all patients admitted to the hospital between August 26 and September 8, 2021 with a positive SARS-CoV-2 reverse transcription polymerase chain reaction-confirmed infection who were fully vaccinated against COVID-19 were evaluated. Clinical, laboratory data, and outcomes were collected and assessed. All patients had chest imaging performed (either radiography, CT, or a combination of both). Chest radiographs and CTs were assessed and scored on admission and on follow up to determine the extent and type of pulmonary involvement.

The study found that most patients (57%) had a normal chest radiograph. The most common findings on abnormal chest radiographs were a combination of hazy opacities and consolidation. In those patients who had follow-up radiographs, 75% (three of four) demonstrated stable to decreased opacities. The most common imaging findings on a chest CT were ground glass opacities which were observed in 60% (three of five) of the patients. In those patients who had follow-up chest CT, all demonstrated improvement in parenchymal findings, with one patient demonstrating signs of post infectious lung disease and/or chronic lung disease. A majority (75%; six of eight) of the hospitalized patients with breakthrough COVID-19 received the Pfizer-BioNTech vaccine.

The majority of the patients (75%; six of eight) reported mild respiratory symptoms prior to presentation, and one patient presented with gastrointestinal and genitourinary symptoms at the time of admission. As of the end of the study, six of eight patients were discharged without residual respiratory symptoms. Although two patients required ICU admission, one was discharged with no residual respiratory symptoms on room air, and the second patient was transferred to a medical floor on room air and without residual respiratory symptoms.

Thus, the majority of the patients with COVID-19 breakthrough illness had absent or mild imaging findings and a benign clinical course. The results are in line with the clinical findings of COVID-19 breakthrough as reported in the literature, demonstrating that imaging findings in such patients are commonly mild. While larger studies are needed to establish imaging differences between breakthrough and unvaccinated populations, awareness of the variability of COVID-19 breakthrough imaging findings is critical. As the number of COVID-19 breakthrough cases is likely to increase, it will be important to continually document imaging findings to determine if the imaging patterns remain consistent with those observed in this study or whether they evolve, according to the researchers.

Related Links:
University of Maryland School of Medicine 

BMP Whole Blood Analyzer: GEM Premier ChemSTAT
Gold Supplier
SBRT Phantom with Removable Spine
E2E SBRT Phantom with Removable Spine Model 036S-CVXX-xx
New
Oxygen Hood
Oxygen Hood
New
OB/GYN Stretcher
Hillrom OB/GYN Stretcher

Print article

Channels

AI

view channel
Image: EchoGo Heart Failure is the first and only AI-enabled HFpEF detection platform for echocardiography (Photo courtesy of Ultromics)

AI Solution for Echocardiography to Revolutionize Diagnosis of Heart Failure with Preserved Ejection Fraction

Heart failure with preserved ejection fraction (HFpEF) is a type of heart failure often associated with co-morbidities and tends to be caused by increased pressure within the chambers of the heart.... Read more

Critical Care

view channel
Image: Lodestar DX provides lab-accurate test results in 30 minutes (Photo courtesy of Llusern Scientific)

Portable UTI Molecular Diagnostic Platform Provides Accurate Test Results in 40 Minutes

Despite being one of the most common types of infection Urinary Tract Infections (UTIs) are a comparatively neglected area of medicine. There are no highly accurate diagnostic tools available for point-of-care... Read more

Surgical Techniques

view channel
Image: ActivSight Intelligent Light has received CE Mark approval (Photo courtesy of Activ Surgical)

Enhanced Imaging System to Become a Game-Changer in the OR by Revolutionizing Surgical Vision

Critical structure identification and tissue perfusion assessment are essential for patients to have the best possible chance of healing well without facing life-threatening or costly complications.... Read more

Patient Care

view channel
Image: Automated cleaning system allows endoscopes to be cleaned direct from clinic (Photo courtesy of Aston University)

World’s First Automated Endoscope Cleaner Fights Antimicrobial Resistance

Endoscopes are long, thin tubes with a light and camera at one end. Due to the sensitivity of the materials and electronics they cannot be sterilized in an autoclave (a machine that uses steam under pressure),... Read more

Health IT

view channel
Image: Using digital data can improve health outcomes (Photo courtesy of Unsplash)

Electronic Health Records May Be Key to Improving Patient Care, Study Finds

When a patient gets transferred from a hospital to a nearby specialist or rehabilitation facility, it is often difficult for personnel at the new facility to access the patient’s electronic health records... Read more

Business

view channel
Image: The global multiparameter patient monitoring systems market is expected to surpass USD 15 billion by 2028 (Photo courtesy of Unsplash)

Global Multiparameter Patient Monitoring Systems Market Driven by Rising Chronic Illnesses

Multi-parameter patient monitoring equipment is used to assess the vital signs of patients who are suffering from a serious illness. These devices are meant to give the number of data sets on one screen... Read more
Copyright © 2000-2022 Globetech Media. All rights reserved.