We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.
09 Dec 2022 - 11 Dec 2022

Testing for Blood Fats Prior to Heart Surgery Could Reduce Postoperative Bleeding

By HospiMedica International staff writers
Posted on 13 Oct 2022
Print article
Image: The new solution could avoid postoperative bleeding in heart surgery (Photo courtesy of IGC)
Image: The new solution could avoid postoperative bleeding in heart surgery (Photo courtesy of IGC)

Postoperative bleeding is one of the most common complications after cardiac surgeries, especially in open heart ones. In this kind of surgery, surgeons need to resort to cardiopulmonary bypass, an extracorporeal circuit composed of tubes and machines that replicate the function of the heart and lungs. This allows them to work inside of the heart while it remains still and bloodless. Despite its undeniable utility, the circulation of the blood outside of the body affects the number and function of components that are responsible for coagulation, the platelets. As such, to prevent or make up for bleeding, patients often need blood transfusions, which not only increases their risk of death but also brings considerable healthcare costs. Now, researchers have revealed a new way to reduce blood loss in heart surgeries by identifying changes in blood fat levels that relate to the patients’ risk of bleeding. With a simple test before the surgery, clinicians could anticipate this postoperative complication and act to prevent it.

Intending to find molecular signatures that could inform the prognosis, researchers from the Instituto Gulbenkian de Ciência (IGC, Oeiras, Portugal) studied blood samples from 33 patients undergoing heart valve replacement surgery. The samples were drawn before and six and 24 hours after the surgery and compared between patients with and without postoperative bleeding. Changes in the levels of fats belonging to the omega-6 family in these patients’ blood caught the researchers’ attention. Curiously, patients with low levels of this fat in the blood before the surgery lost more blood and needed nearly twice as many postoperative transfusions. Although these fats were known to regulate the aggregation of platelets to form clots, these had never been related with the risk of bleeding.

Postoperative bleeding was also higher in patients whose omega-6 levels decreased between the pre and postoperative time points. The alteration could be attributed to yet another example of the complex crosstalk between surgery-related inflammation and coagulation, according to the researchers. An important inflammatory mediator, known for increasing the number and stimulating the function of platelets, seems to be related to the variability in the patients’ blood fat. In particular, this pro-inflammatory mediator seems to decrease in patients with significant bleeding. As such, inflammation could be the reason behind the alterations in this fat and, consequently, the dysfunction of platelets following heart surgery.

In summary, the study showed that changes in the levels of fats from the omega-6 family, associated with inflammation, are characteristic of heart surgery with cardiopulmonary bypass. Supplementation with this fat before surgery could be a safe and inexpensive option to secure the normal functioning of these blood components. The researchers are already planning a study “to evaluate the efficacy of this strategy in reducing bleeding and transfusions after surgery”.

“Assessing the level of this fat in the blood before surgery could be more relevant than looking at the number of platelets,” explained Luís Moita, principal investigator of the Innate Immunity and Inflammation group at the IGC, and also doctor by training.

Related Links:
Instituto Gulbenkian de Ciência 

BMP Whole Blood Analyzer: GEM Premier ChemSTAT
Gold Supplier
POC Test Reader
H.pylori Diagnostic Kit
Helicosign Dry
Automatic IFA Processor

Print article



view channel
Image: AI transforms smartwatch ECG signals into a diagnostic tool for heart failure (Photo courtesy of Pexels)

AI-Based Smartwatch Accurately Detects Heart Failure Using ECG Signals

People with a weak heart pump might not have symptoms, but this common form of heart disease affects about 2% of the population and 9% of people over 60. When the heart cannot pump enough oxygen-rich blood,... Read more

Surgical Techniques

view channel
Image: CystoSmart image enhancement and AI diagnostic tool will enhance cancer detection (Photo courtesy of Claritas HealthTech)

AI Diagnostic Tool Improves Cancer Detection in Cystoscope Images of Bladder

Bladder cancer is the 10th commonest cancer worldwide and the 6th commonest cancer amongst men. It is known to have high recurrence rates and significant risks of disease progression. Early detection of... Read more

Patient Care

view channel
Image: Automated cleaning system allows endoscopes to be cleaned direct from clinic (Photo courtesy of Aston University)

World’s First Automated Endoscope Cleaner Fights Antimicrobial Resistance

Endoscopes are long, thin tubes with a light and camera at one end. Due to the sensitivity of the materials and electronics they cannot be sterilized in an autoclave (a machine that uses steam under pressure),... Read more

Health IT

view channel
Image: Using digital data can improve health outcomes (Photo courtesy of Unsplash)

Electronic Health Records May Be Key to Improving Patient Care, Study Finds

When a patient gets transferred from a hospital to a nearby specialist or rehabilitation facility, it is often difficult for personnel at the new facility to access the patient’s electronic health records... Read more


view channel
Image: The global multiparameter patient monitoring systems market is expected to surpass USD 15 billion by 2028 (Photo courtesy of Unsplash)

Global Multiparameter Patient Monitoring Systems Market Driven by Rising Chronic Illnesses

Multi-parameter patient monitoring equipment is used to assess the vital signs of patients who are suffering from a serious illness. These devices are meant to give the number of data sets on one screen... Read more
Copyright © 2000-2022 Globetech Media. All rights reserved.