We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.
09 Dec 2022 - 11 Dec 2022

Rapid Blood Test Predicts Organ Transplant Rejection in Six Hours

By HospiMedica International staff writers
Posted on 13 Oct 2022
Print article
Image: The PlexAPR blood test rapidly measures rejection risk of transplanted abdominal organs (Photo courtesy of Pexels)
Image: The PlexAPR blood test rapidly measures rejection risk of transplanted abdominal organs (Photo courtesy of Pexels)

Patients receiving solid organ transplants can face rejection due to recipient T-cells which injure the transplanted organ directly, or anti-donor antibodies, which are produced by B-cells of the recipient. Rejection is diagnosed with biopsies which are performed when dysfunction of the transplanted organ is suspected from clinical symptoms and blood tests. However, biopsies are invasive, take time to arrange and do not clearly distinguish between some types of viral infection which may co-exist with rejection. Rapid non-invasive surveillance of organ health can improve survival and quality of life after transplantation. Now, a six-hour blood test to predict organ transplant rejection will allow clinicians to react sooner and improve management of transplanted organs experiencing organ dysfunction, while confirmatory biopsies are being arranged.

Plexision (Pittsburgh, PA, USA) has completed development of PlexAPR - a six-hour blood test to predict organ transplant rejection. When combined with other clinical and laboratory information, rapid rejection-risk assessment can allow caregivers to intervene early, while arranging confirmatory biopsies, or during lifelong surveillance of organ health. PlexAPR is based on the presentation of donor antigen by circulating antigen presenting cells, such as B-cells. The test readout is a personalized index, only applicable to the patient being tested. Patient samples will be tested at the company’s CLIA- and CAP-accredited reference laboratory.

“Transplant rejection can happen at any time after transplantation and requires lifelong management of anti-rejection medications. Same-day delivery of test results is a valuable addition to personalized rejection-risk assessment and improving outcomes,” said Rajeev Sindhi, CEO of Plexision.

Related Links:

BMP Whole Blood Analyzer: GEM Premier ChemSTAT
Gold Supplier
Hematology Workflow Solution
Albumin Urine Test
Micro-Albumin ELISA
Hepatitis/HBcAb CLIA Test

Print article



view channel
Image: AI transforms smartwatch ECG signals into a diagnostic tool for heart failure (Photo courtesy of Pexels)

AI-Based Smartwatch Accurately Detects Heart Failure Using ECG Signals

People with a weak heart pump might not have symptoms, but this common form of heart disease affects about 2% of the population and 9% of people over 60. When the heart cannot pump enough oxygen-rich blood,... Read more

Critical Care

view channel
Image: Quantra Hemostasis Analyzer (Photo courtesy of HemoSonics)

Next-Gen POC Whole Blood Hemostasis System Recognizes Specific Needs of EDs and ORs

Current hemostatic tests provide only a subset of needed information, or take too long to be useful in critical bleeding situations, forcing clinicians to use iterative transfusion protocols that do not... Read more

Surgical Techniques

view channel
Image: CystoSmart image enhancement and AI diagnostic tool will enhance cancer detection (Photo courtesy of Claritas HealthTech)

AI Diagnostic Tool Improves Cancer Detection in Cystoscope Images of Bladder

Bladder cancer is the 10th commonest cancer worldwide and the 6th commonest cancer amongst men. It is known to have high recurrence rates and significant risks of disease progression. Early detection of... Read more

Patient Care

view channel
Image: Automated cleaning system allows endoscopes to be cleaned direct from clinic (Photo courtesy of Aston University)

World’s First Automated Endoscope Cleaner Fights Antimicrobial Resistance

Endoscopes are long, thin tubes with a light and camera at one end. Due to the sensitivity of the materials and electronics they cannot be sterilized in an autoclave (a machine that uses steam under pressure),... Read more

Health IT

view channel
Image: Using digital data can improve health outcomes (Photo courtesy of Unsplash)

Electronic Health Records May Be Key to Improving Patient Care, Study Finds

When a patient gets transferred from a hospital to a nearby specialist or rehabilitation facility, it is often difficult for personnel at the new facility to access the patient’s electronic health records... Read more


view channel
Image: The global multiparameter patient monitoring systems market is expected to surpass USD 15 billion by 2028 (Photo courtesy of Unsplash)

Global Multiparameter Patient Monitoring Systems Market Driven by Rising Chronic Illnesses

Multi-parameter patient monitoring equipment is used to assess the vital signs of patients who are suffering from a serious illness. These devices are meant to give the number of data sets on one screen... Read more
Copyright © 2000-2022 Globetech Media. All rights reserved.