We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App

Respiratory Discovery Could Improve Survival of COVID-19 Intensive Care Patients

By HospiMedica International staff writers
Posted on 15 Dec 2021
Print article

A clinical trial has revealed one reason why COVID-19 patients on ventilators have trouble breathing, and how refining a treatment could help save lives.

The COVID-19 virus latches onto cells deep in our lungs that produce surfactant – a complex mixture which lines our lungs’ air sacs and is essential for breathing. The research team at the University of Southampton (Southampton, UK) and University College London (London, UK) has shown COVID-19 patients on ventilators had less surfactant, and discovered why giving extra surfactant doesn’t always work. They suggest that, by giving surfactant for longer, more intensive care patients could survive.

Surfactant helps to reduce the surface tension of water that lines the air sacs of the lungs, making it easier to breathe. It was first found to be important in premature babies, who have less surfactant when they are born. This can lead to a condition known as Infant Respiratory Distress Syndrome, which is routinely treated successfully by given artificial surfactant to top up their surfactant levels and help them breathe more easily. A similar condition in adults, known as Adult Respiratory Distress Syndrome (ARDS), affects critically ill patients with severe COVID-19.

The new pilot study showed that 10 COVID-19 patients with ARDS who were on ventilators had less surfactant than healthy people. The investigators gave the patients Alveofact, a surfactant often used to treat premature babies, as a fine mist into their lungs, and studied how the composition of the surfactant changed. Surfactant is naturally absorbed and replaced by the body over time. But their results show a particularly rapid turnover of the artificial surfactant. It is the first study to show this in COVID-19 patients. This rapid turnover could explain why the benefits of giving replacement surfactant only last for a short while. Giving it for a longer period, they suggest, could help save lives.

“This has very significant implications for the design of future treatments for severe COVID-19,” said Dr. Ahilanandan Dushianthan, a Consultant in General Intensive Care at University Hospital Southampton. “We found that replacement surfactant rapidly cleared with a half-life of about seven hours. This indicates that multiple surfactant doses over a number of days will be required to support breathing while the lung cells repair after the infection passes.”

Related Links:
University of Southampton 
University College London 

Print article


Surgical Techniques

view channel
Image: Persona IQ is a first-to-world smart implant that captures key kinematic data metrics (Photo courtesy of Zimmer Biomet)

World’s First Smart Knee Implant Optimizes Patient Monitoring and Recovery After Surgery

A first-to-world smart knee implant utilizes sensor-based technology to allow physicians and care teams to collect patient-specific kinematic data during the course of patient monitoring.... Read more

Patient Care

view channel
Image: The biomolecular film can be picked up with tweezers and placed onto a wound (Photo courtesy of TUM)

Biomolecular Wound Healing Film Adheres to Sensitive Tissue and Releases Active Ingredients

Conventional bandages may be very effective for treating smaller skin abrasions, but things get more difficult when it comes to soft-tissue injuries such as on the tongue or on sensitive surfaces like... Read more

Health IT

view channel
Image: AI can reveal a patient`s heart health (Photo courtesy of Mayo Clinic)

AI Trained for Specific Vocal Biomarkers Could Accurately Predict Coronary Artery Disease

Earlier studies have examined the use of voice analysis for identifying voice markers associated with coronary artery disease (CAD) and heart failure. Other research groups have explored the use of similar... Read more


view channel
Image: The global capsule endoscopy system market is growing at a rapid pace (Photo courtesy of Pexels)

Capsule Endoscopy System Market Driven by Rising Preference for Minimally Invasive Screening Procedure

Capsule endoscopy is generally a non-invasive technique that enables complete examination of the gastrointestinal tract with the use of the disposable and wireless device known as the video capsule.... Read more
Copyright © 2000-2022 Globetech Media. All rights reserved.