Research Center Tackles Antimicrobial Drugs Challenge

A new state-of-the-art research center aims to accelerate the development of new antibiotics by providing researchers and commercial companies with access to pharmacodynamics research expertise, facilities, and training.

Established by the University of Liverpool, the Liverpool School of Tropical Medicine, and North Bristol NHS Trust, the Centre for Antimicrobial Pharmacodynamics (CAP) will be aligned with antimicrobial resistance (AMR) accelerators in the United States and Europe, and will provide a local resource for around 20 UK and 90 global AMR companies.

CAP will provide a complete, integrated drug development package, including experimental models for invasive bacterial and fungal diseases, comprised of laboratory animal models, hollow fiber models of infection, and other well characterized in vitro models of infection; advanced pharmacokinetics and pharmacodynamics (PK-PD) mathematical modeling, including population pharmacokinetics, drug interaction modeling, antimicrobial resistance modeling, and Monte Carlo simulation; and bioanalysis run to GCP standards for laboratories.

Other services provided will include preclinical imaging to assess the distribution of small molecules in target tissues and organs; underpinning PK-PD studies in early phase clinical studies in Liverpool or in other clinical research facilities; training future generations of researchers; and running bespoke short courses, plus participation in expert workshops. More...