We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Detecto

Download Mobile App




Events

ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.
16 Feb 2023 - 18 Feb 2023

Research Center Tackles Antimicrobial Drugs Challenge

By HospiMedica International staff writers
Posted on 28 Mar 2017
Print article
Image: The new Liverpool Life Sciences Accelerator will help develop new antibiotics (Photo courtesy of LSTM).
Image: The new Liverpool Life Sciences Accelerator will help develop new antibiotics (Photo courtesy of LSTM).
A new state-of-the-art research center aims to accelerate the development of new antibiotics by providing researchers and commercial companies with access to pharmacodynamics research expertise, facilities, and training.

Established by the University of Liverpool, the Liverpool School of Tropical Medicine, and North Bristol NHS Trust, the Centre for Antimicrobial Pharmacodynamics (CAP) will be aligned with antimicrobial resistance (AMR) accelerators in the United States and Europe, and will provide a local resource for around 20 UK and 90 global AMR companies.

CAP will provide a complete, integrated drug development package, including experimental models for invasive bacterial and fungal diseases, comprised of laboratory animal models, hollow fiber models of infection, and other well characterized in vitro models of infection; advanced pharmacokinetics and pharmacodynamics (PK-PD) mathematical modeling, including population pharmacokinetics, drug interaction modeling, antimicrobial resistance modeling, and Monte Carlo simulation; and bioanalysis run to GCP standards for laboratories.

Other services provided will include preclinical imaging to assess the distribution of small molecules in target tissues and organs; underpinning PK-PD studies in early phase clinical studies in Liverpool or in other clinical research facilities; training future generations of researchers; and running bespoke short courses, plus participation in expert workshops. The CAP is also the first project to be announced as part of the newly launched Centre of Excellence in Infectious Diseases Research (CEIDR), a joint collaboration between the University of Liverpool and LSTM.

“Characterizing the preclinical and clinical pharmacokinetics and pharmacodynamics of anti-infective drugs is a relatively recent and mandatory regulatory requirement, which has created a bottleneck for AMR project progression because there is a lack of global skills and capacity to meet demand,” said Professor William Hope, MD, PhD, who will lead CAP. “The CAP will build on Liverpool’s existing strength in antimicrobial pharmacodynamics and therapeutics research to give scientists access to the skills and equipment they need to advance the development of new antibiotics.”

The new CAP facility will receive infrastructure funding from Innovate UK, an executive non-departmental public body of the UK government. In addition to the Innovate UK funding, the University of Liverpool will invest in new senior academic posts, while LSTM will contribute state-of-the-art laboratory space in the Liverpool Life Sciences Accelerator building, which is due to open in late 2017.

Gold Supplier
Newborn Hemoglobin Screening System
VARIANTnbs
New
Blood Warmer
SAHARA-III 230 V
New
Handheld POC Ultrasound
P09
New
Flexible Examination Light
ri-magic LED

Print article

Channels

AI

view channel
Image: A novel research study moves the needle on predicting coronary artery disease (Photo courtesy of Pexels)

AI-Enabled ECG Analysis Predicts Heart Attack Risk Nearly as well as CT Scans

Increased coronary artery calcium is a marker of coronary artery disease that can lead to a heart attack. Traditionally, CT scans are used to diagnose buildup of coronary artery calcium, although CT scanners... Read more

Critical Care

view channel
Image: New spray fights infections and antibiotic resistance (Photo courtesy of Chalmers University of Technology)

Hydrogel-Based Spray Kills Antibiotic-Resistant Bacteria in Wounds and Biomedical Implants

Antibiotic resistance has been ranked among the top ten threats to global health by the World Health Organization (WHO). Antibiotic-resistant bacteria is estimated to cause almost 1.3 million deaths annually... Read more

Health IT

view channel
Image: Using digital data can improve health outcomes (Photo courtesy of Unsplash)

Electronic Health Records May Be Key to Improving Patient Care, Study Finds

When a patient gets transferred from a hospital to a nearby specialist or rehabilitation facility, it is often difficult for personnel at the new facility to access the patient’s electronic health records... Read more

Point of Care

view channel
Image: Steripath improves the diagnostic accuracy and timeliness of sepsis test results (Photo courtesy of Magnolia)

All-in-One Device Reduces False-Positive Diagnostic Test Results for Bloodstream Infections

Blood cultures are considered the gold standard diagnostic test for the detection of blood stream infections, such as sepsis. However, positive blood culture results can be frequently wrong, and about... Read more

Business

view channel
Image: The global endoscopy equipment market is projected to surpass USD 40 billion by 2027 (Photo courtesy of Pexels)

Global Endoscopy Equipment Market Driven by Growing Hospital Investment in Advanced Instruments

The global endoscopy equipment market is projected to register a CAGR of 7% from USD 28.9 billion in 2022 to USD 40.6 billion by 2027, driven by increasing demand for endoscopy to diagnose and treat target... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.