We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
GC Medical Science corp.

Download Mobile App





Gilead’s Antiviral Remdesivir Prevents Disease Progression in Monkeys with COVID-19

By HospiMedica International staff writers
Posted on 21 Apr 2020
A study by the National Institutes of Health’s National Institute of Allergy and Infectious Diseases {(NIAID) Rockville, MD, USA} has found that early treatment with Gilead Sciences’ (Foster City, CA, USA) remdesivir significantly reduced clinical disease and damage to the lungs of rhesus macaques infected with SARS-CoV-2. More...
The study was designed to follow dosing and treatment procedures used for hospitalized COVID-19 patients being administered the experimental antiviral drug in a large, multi-center, clinical trial

The study involved two groups of six rhesus macaques, with one group receiving remdesivir and the other animals being served as an untreated comparison group. The scientists infected both the groups with SARS-CoV-2 and administered an intravenous dose of remdesivir to the treatment group after 12 hours, followed by a daily intravenous booster dose for the next six days. The scientists timed the initial treatment to occur shortly before the virus reached its highest level in the animals’ lungs.

The scientists examined all animals 12 hours after the initial treatment and found the six treated animals to be in significantly better health than the untreated group, with the trend continuing over the course of the seven-day study. One of the six treated animals exhibited mild breathing difficulty, whereas all the six untreated animals showed rapid and difficult breathing. The amount of virus found in the lungs of the animals in the treatment group was significantly than those in the untreated group, and SARS-CoV-2 caused less damage to the lungs of the treated animals than the untreated animals.

The scientists believe that the data supports initiating remdesivir treatment in COVID-19 patients as early as possible to achieve maximum treatment effect, although they have noted that while remdesivir helped prevent pneumonia, it did not reduce virus shedding by the animals.

Related Links:
Gilead Sciences
National Institute of Allergy and Infectious Diseases



Gold Member
SARS‑CoV‑2/Flu A/Flu B/RSV Sample-To-Answer Test
SARS‑CoV‑2/Flu A/Flu B/RSV Cartridge (CE-IVD)
Gold Member
STI Test
Vivalytic Sexually Transmitted Infection (STI) Array
New
Pediatric Cast Saw
CSP-201 Quietcast
New
Pocket Fetal Doppler
CONTEC10C/CL
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to HospiMedica.com and get access to news and events that shape the world of Hospital Medicine.
  • Free digital version edition of HospiMedica International sent by email on regular basis
  • Free print version of HospiMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of HospiMedica International in digital format
  • Free HospiMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Patient Care

view channel
Image: The portable biosensor platform uses printed electrochemical sensors for the rapid, selective detection of Staphylococcus aureus (Photo courtesy of AIMPLAS)

Portable Biosensor Platform to Reduce Hospital-Acquired Infections

Approximately 4 million patients in the European Union acquire healthcare-associated infections (HAIs) or nosocomial infections each year, with around 37,000 deaths directly resulting from these infections,... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.