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16 Feb 2023 - 18 Feb 2023

Elastic Sealant Protects Suture Line After Gastro Surgery

By HospiMedica International staff writers
Posted on 30 Aug 2015
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Image: Sylys Surgical Sealant placed over an anastomosis staple line (Photo courtesy of Cohera Medical).
Image: Sylys Surgical Sealant placed over an anastomosis staple line (Photo courtesy of Cohera Medical).
A novel synthetic sealant has been specifically designed to help reduce leaks after gastrointestinal (GI) anastomosis procedures.

Sylys Surgical Sealant helps reduce anastomotic leakage in GI procedures by providing additional support to the anastomosis during the first few days of healing, when the development of leaks is most likely to occur. The elastic, resorbable, synthetic sealant protects the suture or staple line used in standard anastomotic closure techniques, supporting the anastomosis during the first few days of healing when leaks are most likely to occur. The rapid curing, single-part sealant provides good adherence to tissue, creating a flexible, elastic seal over the anastomosis site.

The curing process is initiated by contact of the viscous fluid with the moisture in the tissue. The cured sealant forms a network of large polymeric chains that allows it to remain soft and flexible, while also creating a strong tissue bond. The sealant remains well adhered to the tissue during the first two weeks after surgery, and then proceeds to break down into harmless subcomponents over a period of three months. Burst strength testing of the product shows that it is able to withstand pressures over 150 mmHg, twice that of normal bowel peristalsis. Sylys Surgical Sealant is a product of Cohera Medical (Pittsburg, PA, USA), and has received the European Community CE marking of approval.

“Sylys enhances standard closure techniques, advancing the healing process and reducing postoperative complications,” said Patrick Daly, President and CEO of Cohera Medical. “We are a step closer to providing patients with the best opportunity for a successful outcome following intestinal anastomosis procedures.”

“Anastomotic leak is the most devastating complication associated with intestinal resection, contributing to morbidity and mortality,” said James McCormick, DO, program director for general surgery at Forbes Hospital (Monroeville, PA, USA). “We have made tremendous strides in curtailing the risk associated with intestinal anastomosis, but we are always striving for further improvement and greater patient safety.”

Anastomotic leakage rates following colon resection range on average from 3%–15%. Such leakage is considered the most serious complication of bowel repair, doubling the length of stay and increasing mortality rates as much as ten-fold, with at least one third of the post-surgical mortality after colorectal surgery is attributed to leaks. Beyond the initial mortality risk, reoperation rates after leakage can be as high as 87%, and overall five year survival rates are reduced by 20%.

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