We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.
16 Feb 2023 - 18 Feb 2023

Mechanotransduction Device Treats Small Bowel Syndrome

By HospiMedica International staff writers
Posted on 05 Jan 2022
Print article
Image: The Eclipse XL1 placed inside the shortened small bowel (Photo courtesy of Eclipse Regenesis)
Image: The Eclipse XL1 placed inside the shortened small bowel (Photo courtesy of Eclipse Regenesis)
A prototype spring-like device applies controlled force to expand healthy tissue in patients suffering from short bowel syndrome (SBS).

The Eclipse Regenesis (Menlo Park, CA, USA) XL1 is a small, compressed coil that is placed inside the small intestine, secured at both ends with plication sutures. The natural expansion and contraction of the intestine work against the resistance of the device, leading to a mechanical transduction that stretches the bowel. Over a two to three week period, the compressed coil device slowly expands to its relaxed state, stimulating new tissue growth in the treated segment, and ultimately expanding it to two to three times the segment’s original length (about four cm).

Once the process is complete, the chromic sutures dissolve, allowing the XL1 to pass through the body to be excreted. Treatment length varies, depending on the starting point (amount of small intestine), the end point (how much new intestine is needed) needed to reduce total parenteral nutrition dependence. Preclinical studies show successful lengthening of the bowel, no perforations, and no obstructions. The newly formed tissue looks and acts like normal intestinal tissue with regard to metabolic uptake and contractile function.

“The basic concept is similar to distraction osteogenesis, which orthopedic surgeons have used for years, applying distraction force to broken bone that will grow up to a millimeter a day,” said Andre Bessette, CEO and a co-founder of Eclipse Regenesis. “Patients with SBS have lost more than 50% of their small intestine, so they’ll need more than one device applied or more than one procedure. We are getting close to performing the first-in-human procedure, and we hope to eventually be able to perform this procedure completely endoscopically.”

SBS is a devastating condition where patients struggle to absorb life-sustaining nutrients from their diet. It typically results from intestinal resection due to necrotizing enterocolitis (NEC), which takes place when the lining of the intestinal wall becomes infected and dies. It can also result from birth defects, such as Gastroschisis, Volvulus, Hirschsprung’s Disease, Intestinal Atresia, and other congenital defects. Patients struggle to absorb life-sustaining nutrients from their diet, and many become reliant on total parenteral nutrition (TPN) to survive.

Related Links:
Eclipse Regenesis

Platinum Supplier
STI Test
Vivalytic Sexually Transmitted Infection (STI) Array
Mechanical Ventilator
NKV-550 Series
Surgical Table
Digital Video Colposcope
CS6/CS6 Pro

Print article



view channel
Image: A novel research study moves the needle on predicting coronary artery disease (Photo courtesy of Pexels)

AI-Enabled ECG Analysis Predicts Heart Attack Risk Nearly as well as CT Scans

Increased coronary artery calcium is a marker of coronary artery disease that can lead to a heart attack. Traditionally, CT scans are used to diagnose buildup of coronary artery calcium, although CT scanners... Read more

Critical Care

view channel
Image: The advanced electronic skin could enable multiplex healthcare monitoring (Photo courtesy of Terasaki Institute)

First-of-Its-Kind Electronic Skin Patch Enables Advanced Health Care Monitoring

For some time now, electronic skin (E-skin) patches have been used to monitor bodily physiological and chemical indicators of health. Such monitors, placed on the skin, are capable of measuring various... Read more

Health IT

view channel
Image: Using digital data can improve health outcomes (Photo courtesy of Unsplash)

Electronic Health Records May Be Key to Improving Patient Care, Study Finds

When a patient gets transferred from a hospital to a nearby specialist or rehabilitation facility, it is often difficult for personnel at the new facility to access the patient’s electronic health records... Read more

Point of Care

view channel
Image: Steripath improves the diagnostic accuracy and timeliness of sepsis test results (Photo courtesy of Magnolia)

All-in-One Device Reduces False-Positive Diagnostic Test Results for Bloodstream Infections

Blood cultures are considered the gold standard diagnostic test for the detection of blood stream infections, such as sepsis. However, positive blood culture results can be frequently wrong, and about... Read more


view channel
Image: Researchers expect broader adoption of AI in healthcare in the near future (Photo courtesy of Pexels)

Artificial Intelligence (AI) Could Save U.S. Healthcare Industry USD 360 Billion Annually

The wider adoption of artificial intelligence (AI) in healthcare could save the U.S. up to USD 360 billion annually although its uptake in the industry is presently limited owing to the absence of trust... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.