We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App




Biodegradable Tracheal Stent Relieves Pediatric Airway Obstruction

By HospiMedica International staff writers
Posted on 26 Jan 2021
Print article
Image: Endoscopic images of the stented airway right after implantation, and after 4, 8 and 12 weeks of implantation (Photo courtesy of Nature Communications Biology)
Image: Endoscopic images of the stented airway right after implantation, and after 4, 8 and 12 weeks of implantation (Photo courtesy of Nature Communications Biology)
An ultrahigh ductility Magnesium (Mg) alloy tracheal stent can help treat pediatric laryngotracheal stenosis (LTS), according to a new study.

Developed at the University of Pittsburgh (Pitt; PA, USA) and the Chinese Academy of Sciences (CAS; Shenyang, China), the balloon-expandable ultra-high ductility LZ61-KBMS (Kumta Bioresorbable Magnesium Stents) tracheal stents are made of a Mg-Li-Zn multiphase alloy designed to provide a less invasive, more effective management technique for LTS that maintains airway patency while safely degrading over time, thus addressing the complications and morbidity issues of existing treatments.

For the study, the researchers used the prototype LZ61-KBMS in an in-vitro rat tracheal bypass model, demonstrating superior mechanical properties, a low degradation rate, excellent biocompatibility, and corrosion resistance. LZ61-KBMS were then implanted in-vivo into a healthy rabbit trachea to evaluate degradation and airway tissue response, with commonly used 316L stainless steel commercial non-degradable stents serving control. The results provided early stage preclinical evidence that validated LZ61-KBMS stents potential for pediatric LTS treatment. The study was published on December 18, 2020, in Nature Communications Biology.

“Our results are very promising for the use of this novel biodegradable, high ductility metal stent, particularly for pediatric patients,” said senior author Professor Prashant Kumta, PhD, of the University of Pittsburgh. “We hope this new approach leads to new and improved treatments for patients with this complex condition as well as other tracheal obstruction conditions, including tracheal cancer.”

LTS is an abnormal narrowing of the central air passageways requiring endoscopic techniques, surgical repair, tracheostomy, or deployment of stents to hold the airway open and enable breathing. Severely stenotic pediatric patients undergo multiple temporizing endoscopic procedures, with over two-thirds requiring open surgical revision, typically accompanied by recurrent scarring, poor wound healing, or life-threatening anastomotic disruption, with a temporary intraluminal airway stent commonly providing graft stability and reinforcement.

Related Links:
University of Pittsburgh
Chinese Academy of Sciences


Gold Member
SARS‑CoV‑2/Flu A/Flu B/RSV Sample-To-Answer Test
SARS‑CoV‑2/Flu A/Flu B/RSV Cartridge (CE-IVD)
Gold Member
POC Blood Gas Analyzer
Stat Profile Prime Plus
Silver Member
Wireless Mobile ECG Recorder
NR-1207-3/NR-1207-E
New
Needlefree Closed System Transfer Device
ChemoClave

Print article

Channels

Critical Care

view channel
Image: The permeable wearable electronics developed for long-term biosignal monitoring (Photo courtesy of CityUHK)

Super Permeable Wearable Electronics Enable Long-Term Biosignal Monitoring

Wearable electronics have become integral to enhancing health and fitness by offering continuous tracking of physiological signals over extended periods. This monitoring is crucial for understanding an... Read more

Patient Care

view channel
Image: The newly-launched solution can transform operating room scheduling and boost utilization rates (Photo courtesy of Fujitsu)

Surgical Capacity Optimization Solution Helps Hospitals Boost OR Utilization

An innovative solution has the capability to transform surgical capacity utilization by targeting the root cause of surgical block time inefficiencies. Fujitsu Limited’s (Tokyo, Japan) Surgical Capacity... Read more

Health IT

view channel
Image: First ever institution-specific model provides significant performance advantage over current population-derived models (Photo courtesy of Mount Sinai)

Machine Learning Model Improves Mortality Risk Prediction for Cardiac Surgery Patients

Machine learning algorithms have been deployed to create predictive models in various medical fields, with some demonstrating improved outcomes compared to their standard-of-care counterparts.... Read more

Point of Care

view channel
Image: The PATHFAST hs-cTnI-II high-sensitivity troponin assay has been developed for the PATHFAST Biomarker Analyzer (Photo courtesy of Polymedco)

POC Myocardial Infarction Test Delivers Results in 17 Minutes

Chest pain is the second leading cause of emergency department (ED) visits by adults in the United States, generating over 7 million visits annually. In the event of a suspected heart attack, physicians... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.