We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

Cellularized Skin Scaffold Treats Deep Partial-Thickness Burns

By HospiMedica International staff writers
Posted on 08 Jul 2021
Print article
Image: StrataGraft  can help burn wounds heal better (Photo courtesy of Stratatech)
Image: StrataGraft can help burn wounds heal better (Photo courtesy of Stratatech)
A new treatment for deep partial-thickness thermal burns helps reduce the amount of autograft needed for future surgery.

The Stratatech (Madison, WI, USA) StrataGraft is made of human keratinocytes and dermal fibroblasts that are grown together to form a bi-layered rectangular sheet, mimicking natural human skin with both inner dermis-like and outer epidermis-like layers. The cellular construct is meshed (dotted with slits), similar to an autograft prepared for surgical use, and is applied to the burn wound by suturing, stapling, or with an adhesive to provide initial coverage during the healing process.

StrataGraft is produced using patented Near-Diploid Immortal Keratinocytes (NIKS) cells and human dermal fibroblasts, all of which have been thoroughly characterized, helping to ensure delivery of tissue that is virus-free, non-tumorigenic, and consistent genetically batch to batch. NIKS keratinocyte progenitor cells also produce growth factors that stimulate regeneration of the patient’s own skin cells, while evoking a very limited immune response.

“We are hopeful that the presence of our tissue will enable the patient’s own tissue to heal underneath over time without taking that autograft. So we are going to be reducing surgical procedures and eliminating a lot of pain and hopefully promoting wound healing,” said Lynn Allen-Hoffmann, MD, PhD, founder of Stratatech, which is now part of Mallinckrodt ( Staines-upon-Thames, United Kingdom). “We can make it, stockpile or store it for a period of time, and then get it out to clinical sites as its needed.”

Deep partial-thickness burns affect all layers of the skin, and may cause damage down to underlying muscles. These burns carry severe risk for complications, such as infections, blood loss and shock, which could lead to organ failure or death. The current standard of care for severe burns is skin-grafting, or autografting, which is the surgical harvest of healthy skin from an uninjured site on the patient’s body followed by transplant to the wound. It results in a donor site wound that requires medical management of pain, and may result in infection and/or scarring.

Related Links:

Print article



view channel

44th IHF World Hospital Congress Presents Over 60 Plenary Sessions and 200 Renowned Speakers Across Four-Day Event

The 44th World Hospital Congress organized by The International Hospital Federation (Geneva, Switzerland) will bring together more than 200 healthcare experts, leading industry thinkers, and best practice... Read more
Copyright © 2000-2021 Globetech Media. All rights reserved.