We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Feather Safety Razor

Download Mobile App

Urinary Proteome Analysis Predicts Transition from Moderate to Severe Disease in COVID-19 Progression

By HospiMedica International staff writers
Posted on 21 Mar 2022
Print article
Image: Urine proteome contains clues to what is happening inside the human body (Photo courtesy of Unsplash)
Image: Urine proteome contains clues to what is happening inside the human body (Photo courtesy of Unsplash)

Since the pandemic broke out, a team of researchers working in the forefront line of compacting COVID-19 disease have been investigating whether they could find clues for what happened to the living COVID-19 patients at the molecular level. As urine can be readily obtained from living people, they looked at all kinds of proteins in the urine. Their latest findings suggest that urine may provide a window for us to see what is happening inside the human body and predict the transition from moderate to severe disease in COVID-19 progression.

By applying LC/MS-MS-based proteomics, scientists at the National Center for Protein Sciences (Beijing, China) analyzed 317 urine proteomes from 86 COVID-19 and 55 pneumonia patients and 176 healthy controls, they identified 4,255 proteins from the urine, in which proteins with functions of immune and metabolism were among the most significantly altered after SARS-CoV-2 infection. It was exciting and reassuring to find proteins in the anti-virus response pathway from the urinary proteome, including the up-regulated dsRNA detector DDX58/RIG-I, the virus response specific transcription factor STAT1, and a collection of ISG proteins.

Trawling through the data, the scientists came across an under-studied protein, CLYBL, which was not included in the commonly used database for annotation in bioinformatics. CLYBL, a citramalyl-CoA lyase, catalyzes the transition of itaconate to acetyl-CoA in the TCA cycle. Thus, increased CLYBL indeed led to the consumption of anti-inflammatory metabolite itaconate in COVID-19 patients. As Itaconate was shown to play an important role in antioxidation, cellular protection, and anti-inflammation, these observations led to the speculation that supplement of itaconate along or with inhibition of CLYBL might be possible therapeutic options for treating COVID-19 patients.

By comparing the proteomes of the early-disease-stage patients who later turned into severity with those of the patients who remained moderate across disease progression, the team identified a number of proteins, which may predict the transition from moderate to severe disease in COVID-19 progression. Increased levels of CD14, RBP4, SPON2, GMFG, SERPINA1, SERPINB6 and SERPINC1 in severe COVID-19 patients and their known biological functions suggested that macrophage-induced inflammation and thrombolysis may play a critical role in worsening the disease.

The current study showed that the urine proteome contained clues to what is happening inside the human body. It is a convenient source of biological samples that can be obtained from living people under physiological and pathological conditions. Peeking through the urine proteome, one can find signaling pathways as well as potential drug targets. In this specific COVID-19 case, the finding that the endogenous immune-modulating metabolite itaconate as a potential therapy option for treating the disease is particular timely, as an immune modulating therapy is independent of mutating virus, say it is Delta or Omicron.

Related Links:
National Center for Protein Sciences 

Print article
IIR Middle East


Critical Care

view channel
Image: Three dimensional measurement of the all-mesh thermistor (Photo courtesy of Shinshu University)

Ultraflexible, Gas-Permeable Thermistors to Pave Way for On-Skin Medical Sensors and Implantable Devices

On-skin medical sensors and wearable health devices are important health care tools that must be incredibly flexible and ultrathin so they can move with the human body. In addition, the technology has... Read more

Surgical Techniques

view channel
Image: Engineers have developed a process that enables soft robots to grow like plants (Photo courtesy of University of Minnesota)

Soft Robotic System Can Grow Like Plants to Allow Surgical Access to Hard-To-Reach Areas

Soft robotics is an emerging field where robots are made of soft, pliable materials as opposed to rigid ones. Soft growing robots can create new material and “grow” as they move. These machines could be... Read more

Patient Care

view channel
Image: The biomolecular film can be picked up with tweezers and placed onto a wound (Photo courtesy of TUM)

Biomolecular Wound Healing Film Adheres to Sensitive Tissue and Releases Active Ingredients

Conventional bandages may be very effective for treating smaller skin abrasions, but things get more difficult when it comes to soft-tissue injuries such as on the tongue or on sensitive surfaces like... Read more

Health IT

view channel
Image: Using digital data can improve health outcomes (Photo courtesy of Unsplash)

Electronic Health Records May Be Key to Improving Patient Care, Study Finds

When a patient gets transferred from a hospital to a nearby specialist or rehabilitation facility, it is often difficult for personnel at the new facility to access the patient’s electronic health records... Read more


view channel
Image: Differentiated stapling technology for bariatric surgery (Photo courtesy of Standard Bariatrics)

Teleflex Completes Acquisition of Bariatric Stapling Technology Innovator

Teleflex Incorporated (Wayne, PA, USA), a leading global provider of medical technologies, has completed the previously announced acquisition of Standard Bariatrics, Inc. (Cincinnati, OH, USA), which has... Read more
Copyright © 2000-2022 Globetech Media. All rights reserved.