We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Varian Medical Systems

Provides solutions for advancing cancer treatment, radiosurgery, X-ray imaging, & security, radiotherapy, radiosurger... read more Featured Products: More products

Download Mobile App




Events

ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

Microsphere Embolization Technology Treats Knee Osteoarthritis

By HospiMedica International staff writers
Posted on 26 Oct 2021
Print article
Image: Embozene microspheres are color-coded by size (Photo courtesy of Varian)
Image: Embozene microspheres are color-coded by size (Photo courtesy of Varian)
Novel microspheres can alleviate symptomatic knee osteoarthritis (OA) by reducing blood flow to the periarticular tissue of the joints, limiting the inflammatory process.

The Varian Medical Systems (Varian; Palo Alto, CA, USA) Embozene spheres are biocompatible hydrogel microspheres coated with a proprietary polymer (Polyzene-F). The minute spheres are color-coded by size to allow for easy identification, and are delivered pre-compressed to enable smooth delivery via catheter. Embozene microspheres are intended for embolization of arteriovenous malformations and hypervascular tumors, such as uterine fibroids and hepatoma, benign prostatic hyperplasia (BPH), and now for genicular artery embolization (GAE).

GAE is performed under moderate sedation as an outpatient procedure, generally taking one to two hours. The delivery catheter is inserted in a percutaneous procedure under fluoroscopic guidance, with the microspheres conveyed to arteries supplying the inflamed synovium (lining of the knee). By blocking the genicular arteries, there is a reduction in the amount of inflammation associated with OA, which can diminish or eliminate the associated knee pain. Embozene microspheres are packaged in 20 ml syringes, with an approximate 7 ml fill volume across the range.

“GAE holds great promise in providing clinicians with a new, non-invasive treatment option, which may not only ameliorate pain, but reduce the economic burden of this common disease,” said Frank Facchini, MD, president of Varian Interventional Solutions. “Varian's investigational program for GAE exemplifies our commitment to investing in our core technologies to determine their potential to treat the world's most debilitating diseases.”

“GAE is the first minimally invasive procedure that has demonstrated significant symptom improvement for a prolonged duration,” said Siddharth Padia, MD, director of interventional radiology at UCLA Santa Monica (CA, USA). “In a 40-patient, prospective study, the procedure resulted in a marked improvement in pain and function, and adverse events were uncommon and mild. I remain excited about the possibilities of this technology and its benefit to patients.”

OA is a group of abnormalities involving degradation of joints, including articular cartilage and subchondral bone. Symptoms may include joint pain, tenderness, stiffness, locking, and sometimes an effusion. A variety of causes--hereditary, developmental, metabolic, and mechanical deficits--may initiate processes leading to loss of cartilage. As a result of decreased movement secondary to pain, regional muscles may atrophy, and ligaments may become more lax. OA of the knee affects about 250 million people worldwide (3.6% of the population).

Related Links:
Varian Medical Systems


Print article
Clear Image Devices
NUVO

Channels

Business

view channel
Image: 44th World Hospital Congress (WHC) Ends on Upbeat Note as Hospital Leaders Look to Build Resilience (Photo courtesy of IHF)

44th World Hospital Congress (WHC) Ends on Upbeat Note as Hospital Leaders Look to Build Resilience

The 44th World Hospital Congress (WHC) organized by The International Hospital Federation (IHF; Geneva, Switzerland) on 8-11 November 2021 in Barcelona, Spain came to an upbeat close. During the event,... Read more
Copyright © 2000-2021 Globetech Media. All rights reserved.