We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

Novel Coating Might Curb Organ Transplant Rejection

By HospiMedica International staff writers
Posted on 31 Aug 2021
Print article
Image: Synthetic polymers can help protect organs targeted for transplant (Photo courtesy of UBC)
Image: Synthetic polymers can help protect organs targeted for transplant (Photo courtesy of UBC)
Using immunosuppressive polymers to coat blood vessels of organs for transplant can substantially diminish rejection, according to a new study.

Developed at the University of British Columbia (UBC; Vancouver, Canada), Simon Fraser University (Burnaby, Canada), and other institutions, the new synthetic polymer is designed to mimic glycocalyx, an immune-modulating protein that lines blood vessels, which tends to break down during organ procurement as a result of enzymatic ligation of the glycopolymers used during cold ischemic storage. In addition, this ligation subsequently attenuates the acute and chronic rejection of the grafts after transplantation.

For the study, conducted in syngeneic and allogeneic mice that received kidney transplants, the steric and immunosuppressive properties of the ligated polymers largely protected the transplanted grafts from ischaemic reperfusion injury and immune-cell adhesion. A mouse artery coated with the polymer and then transplanted exhibited strong long-term resistance to inflammation and rejection. According to the researchers, the polymer-mediated shielding of endothelial glycocalyx could also reduce the damage and rejection of transplanted organs after surgery. The study was published on August 9, 2021, in Nature Biomedical Engineering.

“We demonstrated that the technology works for blood vessel and complex kidney transplantation in mice. However, the immune system of these animals is slightly different than in humans,” said senior author Jayachandran Kizhakkedathu, PhD, who developed the polymer at the UBC Centre for Blood Research. “Our next step is to investigate the protective effect of the technology in large animal transplantation, including non-human primates. We’re hopeful that this breakthrough will one day improve quality of life for transplant patients and improve the lifespan of transplanted organs.”

The cornerstone of traditional organ preservation is cold ischemic storage. Although this method is intended to reduce the extent of organ damage during transport, significant deterioration of the donated organ still occurs; the longer the organ is kept on ice, the greater the damage.

Related Links:
University of British Columbia
Simon Fraser University

Gold Supplier
SBRT Phantom with Removable Spine
E2E SBRT Phantom with Removable Spine Model 036S-CVXX-xx
Robotic Knee Replacement System
Barrier Mount
RayShield SideWinder
Ventilator Breathing System
Single-Use Ventilator Breathing Systems

Print article



view channel
Image: The WHO has conditionally recommended the use of algorithms in assisting with pediatric tuberculosis diagnosis (Photo courtesy of Pexels)

New Evidence-Based Algorithms Could Improve Diagnosis of Pediatric Tuberculosis

Tuberculosis (TB) continues to be one of the most prevalent causes of death among younger populations worldwide. Research indicates that over 96% of the deadly TB cases in children under the age of 15... Read more

Health IT

view channel
Image: Using digital data can improve health outcomes (Photo courtesy of Unsplash)

Electronic Health Records May Be Key to Improving Patient Care, Study Finds

When a patient gets transferred from a hospital to a nearby specialist or rehabilitation facility, it is often difficult for personnel at the new facility to access the patient’s electronic health records... Read more


view channel
Image: The demand for endometrial ablation devices is increasing due to rising prevalence of gynecological disorders (Photo courtesy of Pexels)

Global Endometrial Ablation Market Driven by Rising Prevalence of Gynecological Disorders

Gynecological disorders, such as menorrhagia, PCOD, abnormal vaginal bleeding, affect millions of women globally every year and are on the rise. Abnormal Uterine Bleeding (AUB) is the most common disorder... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.