We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
77 ELEKTRONIKA

Download Mobile App




Innovative Immunotherapy Treatment Demonstrates 90% Success Rate in Patients with Multiple Myeloma

By HospiMedica International staff writers
Posted on 09 Jun 2023
Print article
Image: Almost 90% of patients showed improvement with a new immunotherapy for multiple myeloma (Photo courtesy of Freepik)
Image: Almost 90% of patients showed improvement with a new immunotherapy for multiple myeloma (Photo courtesy of Freepik)

Multiple myeloma, the second most prevalent blood cancer, has been notoriously resistant to treatment. Until a few years ago, the prognosis for this disease, accounting for one percent of all cancers and 10% of blood cancers, was a mere two-year average life expectancy. The disease's incidence is on the rise, with a projected 176,000 diagnoses worldwide in 2023. Now, a new ray of hope has emerged for those suffering from blood cancer, after nearly 90% of patients who underwent a novel immunotherapy treatment for multiple myeloma showed signs of improvement. Even more impressively, more than half - 57% - achieved remission. Clinical trials for this treatment, called CAR-T, or chimeric antigen receptor T-cell therapy, are set to commence soon in the United States.

CAR-T therapy utilizes a patient’s healthy cells to destroy the cancerous ones. It involves isolating a patient’s T-cells – the proactive cells of the immune system with the ability to fight tumors – using an apheresis machine that separates the blood into red and white cells. Through genetic engineering, a virus and a genetic fragment that encodes a receptor targeting the cancer cells are introduced. These modified cells are then produced in large numbers and reinfused into the patient, where they proceed to seek out and destroy the multiple myeloma cells.

The CAR-T treatment was developed at the Hadassah Medical Organization (New York, NY, USA) in collaboration with researchers at Bar-Ilan University (Ramat Gan, Israel). Immix BioPharma (Los Angeles, CA, USA) has acquired the patent rights to the therapy and plans to soon commence clinical trials in the US with FDA approval likely within a year. The revolutionary concept of harnessing a patient’s own immune system cells to fight cancer cells was first put forward several decades ago. Since then, researchers at the Hadassah Medical Organization have spearheaded the development and promotion of CAR-T. By manufacturing CAR-T at Hadassah, the medical center has managed to make this formerly prohibitive treatment accessible. As the first and sole institution in Israel to develop, produce, and deliver CAR-T treatment, Hadassah is pioneering a field that holds the promise of CAR-T therapies for other cancer types in the future.

“These are dramatic results and offer enormous hope for patients who have a disease that, to date, has been incurable,” said Polina Stepensky, MD, a hematologist-oncologist, pediatrician and stem-cell transplantation expert who directs Hadassah’s Bone Marrow Transplantation Department. “Until now, this treatment has only been available in China and the United States at a cost of nearly USD 400,000 per patient treatment. Only 20% of those who need to receive it in those countries actually get it.”

Related Links:
Hadassah Medical Organization
Bar-Ilan University
Immix BioPharma

Gold Member
12-Channel ECG
CM1200B
Gold Member
Disposable Protective Suit For Medical Use
Disposable Protective Suit For Medical Use
Silver Member
Wireless Mobile ECG Recorder
NR-1207-3/NR-1207-E
New
Ventilation Mode
Neurally Adjusted Ventilatory Assist (NAVA)

Print article

Channels

Surgical Techniques

view channel
Image: Classification of the guidance image applied for surgical robot (Photo courtesy of Science China Press)

Advances in Image-Guided Methods Enabling Intelligent Surgical Robots for Precise Procedures

Traditional image-guided methods often depend on stationary equipment within the operating room, while modern surgical robots are equipped to acquire and process high-precision images in real time during surgeries.... Read more

Patient Care

view channel
Image: The portable, handheld BeamClean technology inactivates pathogens on commonly touched surfaces in seconds (Photo courtesy of Freestyle Partners)

First-Of-Its-Kind Portable Germicidal Light Technology Disinfects High-Touch Clinical Surfaces in Seconds

Reducing healthcare-acquired infections (HAIs) remains a pressing issue within global healthcare systems. In the United States alone, 1.7 million patients contract HAIs annually, leading to approximately... Read more

Health IT

view channel
Image: First ever institution-specific model provides significant performance advantage over current population-derived models (Photo courtesy of Mount Sinai)

Machine Learning Model Improves Mortality Risk Prediction for Cardiac Surgery Patients

Machine learning algorithms have been deployed to create predictive models in various medical fields, with some demonstrating improved outcomes compared to their standard-of-care counterparts.... Read more

Point of Care

view channel
Image: POCT offers cost-effective, accessible, and immediate diagnostic solutions (Photo courtesy of Flinders University)

POCT for Infectious Diseases Delivers Laboratory Equivalent Pathology Results

On-site pathology tests for infectious diseases in rural and remote locations can achieve the same level of reliability and accuracy as those conducted in hospital laboratories, a recent study suggests.... Read more

Business

view channel
Image: The finalists have been announced for the IHF Awards 2024 (Photo courtesy of IHF)

International Hospital Federation Awards 2024 Finalists Announced

The International Hospital Federation (IHF; Geneva, Switzerland) has announced the finalists of the IHF Awards 2024 after the judges completed scoring entries in all 7 Award categories. The IHF Awards... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.