We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
77 ELEKTRONIKA

Download Mobile App




Events

31 Jul 2024 - 02 Aug 2024
02 Aug 2024 - 04 Aug 2024
20 Aug 2024 - 22 Aug 2024

World's Highest-Multiplex POC System with RNA Quantitating Ability Detects Bacterial Infection

By HospiMedica International staff writers
Posted on 20 Nov 2023
Print article
Image: The TriVerity Acute Infection and Sepsis Test System (Photo courtesy of Inflammatix)
Image: The TriVerity Acute Infection and Sepsis Test System (Photo courtesy of Inflammatix)

Sepsis and antimicrobial resistance (AMR) are major contributors to increasing deaths and healthcare costs globally. In clinical settings, diagnosing and treating these conditions present significant challenges. Physicians, especially in emergency rooms, often face difficulties in making prompt, accurate decisions regarding antibiotic use for the roughly 15 million patients annually who present with suspected acute infection and sepsis. In response to this challenge, a new test system specifically designed for emergency department use is being developed. This system aims to evaluate the likelihood of bacterial or viral infections and the risk of acute decompensation, which necessitates ICU-level care, in patients with suspected acute infection and sepsis.

Inflammatix, Inc. (Sunnyvale, CA, USA) has completed technical development for its TriVerity Acute Infection and Sepsis Test System. This system includes the Myrna Instrument and the TriVerity Cartridge. The Myrna Instrument is adept at analyzing up to 64 messenger RNAs (mRNAs) from whole blood or other types of samples within approximately 30 minutes. Designed for potential use at the point-of-care, the Myrna Instrument is aimed to meet the criteria for Clinical Laboratory Improvement Amendments (CLIA) waiver. The accompanying disposable cartridges are designed to be stable at room temperature for up to a year.

The TriVerity Acute Infection and Sepsis Test, a leading product from Inflammatix, utilizes a panel of 29 mRNAs to interpret the body's immune response, assisting in the diagnosis of patients with suspected acute infection and sepsis. This test is particularly targeted at diagnosing patients who present with suspected infections in U.S. emergency departments. Inflammatix is actively working on completing its clinical studies, including the SEPSIS-SHIELD study, which is essential for the submission of the TriVerity Test system to the U.S. Food and Drug Administration (FDA). This multi-center study has already enrolled 955 patients out of the anticipated 1,500. Inflammatix anticipates the completion of the study and the subsequent FDA submission by spring 2024.

"Myrna will be the world's highest-multiplex point-of-care system capable of quantitating RNA, allowing us to bring 'precision medicine' into acute care settings," said Dr. Timothy Sweeney, CEO and co-founder of Inflammatix. "Completing technical development brings TriVerity a step closer to FDA submission and launch, and enables us to execute key clinical studies."

"With the completion of the test system, we look forward to further exploring partnerships that bring existing RNA signatures onto the Myrna ecosystem," Dr. Sweeney commented. "This may be an especially viable pathway given expected changes to the regulation of lab-developed tests and the increased reliance on a biomarker-driven approach to immunotherapy development."

Related Links:
Inflammatix, Inc.

Gold Member
Real-Time Diagnostics Onscreen Viewer
GEMweb Live
Gold Member
SARS‑CoV‑2/Flu A/Flu B/RSV Sample-To-Answer Test
SARS‑CoV‑2/Flu A/Flu B/RSV Cartridge (CE-IVD)
Silver Member
Compact 14-Day Uninterrupted Holter ECG
NR-314P
New
Surgical Needle
PORT-JECT

Print article

Channels

Critical Care

view channel
Image: The first healthcare device to be powered by body heat was made possible by the use of liquid-based metals (Photo courtesy of Carnegie Mellon)

Healthcare Device Powered By Body Heat Marks First Step Toward Battery-Free Wearable Electronics

Portable, wearable electronics for physiological monitoring are gaining preference over traditional tethered devices in clinical settings due to their convenience for continuous or frequent monitoring.... Read more

Surgical Techniques

view channel
Image: Electronic prompt for surgeons may reduce breast cancer overtreatment (Photo courtesy of 123RF)

EHR–Based Nudge Intervention for Surgeons to Reduce Breast Cancer Overtreatment

Sentinel lymph node biopsy (SLNB) is a critical surgical technique used to assess if breast cancer has spread to the underarm lymph nodes, although it's not necessary for all patients. Undergoing SLNB... Read more

Patient Care

view channel
Image: The portable, handheld BeamClean technology inactivates pathogens on commonly touched surfaces in seconds (Photo courtesy of Freestyle Partners)

First-Of-Its-Kind Portable Germicidal Light Technology Disinfects High-Touch Clinical Surfaces in Seconds

Reducing healthcare-acquired infections (HAIs) remains a pressing issue within global healthcare systems. In the United States alone, 1.7 million patients contract HAIs annually, leading to approximately... Read more

Health IT

view channel
Image: First ever institution-specific model provides significant performance advantage over current population-derived models (Photo courtesy of Mount Sinai)

Machine Learning Model Improves Mortality Risk Prediction for Cardiac Surgery Patients

Machine learning algorithms have been deployed to create predictive models in various medical fields, with some demonstrating improved outcomes compared to their standard-of-care counterparts.... Read more

Point of Care

view channel
Image: POCT offers cost-effective, accessible, and immediate diagnostic solutions (Photo courtesy of Flinders University)

POCT for Infectious Diseases Delivers Laboratory Equivalent Pathology Results

On-site pathology tests for infectious diseases in rural and remote locations can achieve the same level of reliability and accuracy as those conducted in hospital laboratories, a recent study suggests.... Read more

Business

view channel
Image: The Innovalve transseptal delivery system is designed to enable safe deployment of the Innovalve implant (Photo courtesy of Innovalve Bio)

Edwards Lifesciences Acquires Sheba Medical’s Innovalve Bio Medical

Edwards Lifesciences (Irvine, CA, USA), a leading company in medical innovations for structural heart disease and critical care, has acquired Innovalve Bio Medical LTD. (Ramat Gan, Israel), an early-stage... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.