We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Sekisui Diagnostics UK Ltd.

Download Mobile App




High-Tech Paint Could Eliminate Need for Multiple Surgeries in Heart and Dialysis Patients

By HospiMedica International staff writers
Posted on 12 Mar 2024
Print article
Image: The epiNanopaint could spare dialysis and heart patients the need for repeated surgeries (Photo courtesy of 123RF)
Image: The epiNanopaint could spare dialysis and heart patients the need for repeated surgeries (Photo courtesy of 123RF)

Vascular surgeons frequently undertake "revascularizations" to treat cardiovascular diseases, restoring blood flow to regions that have either lost it or are receiving inadequate supply. One common example is a vein graft, which involves relocating a vein from one part of the body to another, such as from the leg to the heart in heart failure patients. For those requiring dialysis due to kidney failure, a surgical procedure is used to create an arteriovenous fistula (AVF) by grafting an artery and a vein, usually in the arm. This procedure enables blood to be extracted, cleansed of toxins, and then returned to the body. Despite their necessity, these AVFs demand expensive management in patients with end-stage renal disease.

Moreover, the longevity of revascularizations is compromised over time. The surgical procedures themselves can lead to cell build-up within the vessels, eventually leading to the same issue they aim to resolve: restricted blood flow. Currently, there are no established treatment protocols for maintaining AVFs due to previous ineffective attempts. Consequently, when an AVF fails, which is often the case, patients must undergo repeated surgeries to install new ones. This repetitive cycle can extend to various body parts including both arms, legs, or the collarbone area. Now, researchers are exploring a new approach using nanomedicine, which could be a game changer for affected patients.

Researchers at UVA Health (Charlottesville, VA, USA) are developing a sophisticated method to prevent clogged transplanted veins in heart and dialysis patients, thereby reducing the frequency of surgeries. This method, called epiNanopaint, involves applying adhesive nanoparticles to the vessels during the initial surgery. These nanoparticles are infused with a drug designed to inhibit the growth of invasive cells. Their stickiness ensures they remain in place, enabling the targeted and prolonged release of the drug at the necessary site. The focus of the research is on targeting the enzyme DOT1L with drugs to prevent vessels from narrowing and optimizing the application of this painting technique for drug delivery. Success in this research could revolutionize treatment for countless patients globally.

“Our approach is like deploying tiny guards to protect blood vessels from going bad, so that there is no need to open the body over and over again to repair them,” said Lian-Wang Guo, PhD., of the University of Virginia School of Medicine’s Department of Surgery and the Robert M. Berne Cardiovascular Research Center. “It would save so much pain and money by sparing repeated surgeries.”

Related Links:
UVA Health

Gold Member
STI Test
Vivalytic Sexually Transmitted Infection (STI) Array
Gold Member
Real-Time Diagnostics Onscreen Viewer
GEMweb Live
Silver Member
Compact 14-Day Uninterrupted Holter ECG
NR-314P
New
Color Doppler Ultrasound System
KC20

Print article

Channels

Critical Care

view channel
Image: This study is significant as it addresses a treatment approach that has not been extensively studied before (Photo courtesy of 123RF)

Study Confirms Safety of DCB-Only Strategy for Treating De Novo Left Main Coronary Artery Disease

There has been a lack of extensive research on the use of drug-coated balloon (DCB)-only strategy for the treatment of de novo left main coronary artery disease, especially in high bleeding risk (HBR) patients.... Read more

Patient Care

view channel
Image: The newly-launched solution can transform operating room scheduling and boost utilization rates (Photo courtesy of Fujitsu)

Surgical Capacity Optimization Solution Helps Hospitals Boost OR Utilization

An innovative solution has the capability to transform surgical capacity utilization by targeting the root cause of surgical block time inefficiencies. Fujitsu Limited’s (Tokyo, Japan) Surgical Capacity... Read more

Health IT

view channel
Image: First ever institution-specific model provides significant performance advantage over current population-derived models (Photo courtesy of Mount Sinai)

Machine Learning Model Improves Mortality Risk Prediction for Cardiac Surgery Patients

Machine learning algorithms have been deployed to create predictive models in various medical fields, with some demonstrating improved outcomes compared to their standard-of-care counterparts.... Read more

Point of Care

view channel
Image: The Quantra Hemostasis System has received US FDA special 510(k) clearance for use with its Quantra QStat Cartridge (Photo courtesy of HemoSonics)

Critical Bleeding Management System to Help Hospitals Further Standardize Viscoelastic Testing

Surgical procedures are often accompanied by significant blood loss and the subsequent high likelihood of the need for allogeneic blood transfusions. These transfusions, while critical, are linked to various... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.