We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App




Gastric Banding Equals Metformin in Slowing Diabetes Onset

By HospiMedica International staff writers
Posted on 15 Oct 2018
Print article
A new study shows that gastric banding and metformin have a similar effect on β-cell function in adults with impaired glucose tolerance (IGT) or mild type 2 diabetes (T2D).

Researchers at the University of Southern California (USC; Los Angeles, USA), Kaiser Permanente Southern California (KPSC; Pasadena, USA), and other institutions conducted a study involving 88 adults with a body mass index (BMI) of 30–40 kg/m2 and known IGT or T2D for less than one year in order to compare gastric banding and metformin impact on β-cell function. Arginine injection at maximally potentiating glycemia was performed at baseline, 12 months, and at 24 months to measure steady-state C-peptide (SSCP), acute C-peptide response (ACPRmax), and insulin sensitivity (M/I).

The results revealed that at 24 months, the band group lost 10.7 kg, while the metformin group lost just 1.7 kg. Insulin sensitivity increased 45% in the band group and 25% in the metformin group, and SSCP--adjusted for insulin sensitivity--fell slightly, but not significantly in each group. ACPRmax adjusted for insulin sensitivity fell significantly in the metformin group, but not in the band group. Normoglycemia was present in 22% and 15% of band and metformin groups, respectively, at 24 months. The study was presented at the European Association for the Study of Diabetes annual meeting, held during October 2018 in Berlin (Germany).

“Gastric banding and metformin offered approximately equal approaches for improving insulin sensitivity in adults with mild to moderate obesity and impaired glucose tolerance or early, mild T2D,” said senior author and study presenter Tom Buchanan, MD, chief of the division of endocrinology and diabetes at USC. “The predominant β-cell response was a reduction in secretion to maintain a relatively constant compensation for insulin resistance, with only a small improvement in glucose; whether these interventions will have different effects on β-cell function over the long-term remains to be determined.”

In healthy individuals, pancreatic β-cells release regular pulses of insulin into the bloodstream that restrict the amount of glucose released by the liver, as well as propel body tissues to absorb the released glucose. However, in hyperglycemia, a hallmark of T2D, the excess glucose suppresses the "inner clock" of beta cells that controls the rhythm of insulin pulses, reducing insulin production.

Related Links:
University of Southern California
Kaiser Permanente Southern California

Gold Member
Real-Time Diagnostics Onscreen Viewer
GEMweb Live
Gold Member
12-Channel ECG
CM1200B
Silver Member
Compact 14-Day Uninterrupted Holter ECG
NR-314P
New
LED Examination Light
LED 110

Print article

Channels

Surgical Techniques

view channel
Image: The Early Bird Bleed Monitoring System provides visual and audible indicators of the onset and progression of bleeding events (Photo courtesy of Saranas)

Novel Technology Monitors and Lowers Bleeding Complications in Patients Undergoing Heart Procedures

Bleeding complications at the femoral access site can significantly hamper recovery, affecting the success of procedures, patient satisfaction, and overall healthcare costs. It is crucial for surgeons... Read more

Patient Care

view channel
Image: The newly-launched solution can transform operating room scheduling and boost utilization rates (Photo courtesy of Fujitsu)

Surgical Capacity Optimization Solution Helps Hospitals Boost OR Utilization

An innovative solution has the capability to transform surgical capacity utilization by targeting the root cause of surgical block time inefficiencies. Fujitsu Limited’s (Tokyo, Japan) Surgical Capacity... Read more

Health IT

view channel
Image: First ever institution-specific model provides significant performance advantage over current population-derived models (Photo courtesy of Mount Sinai)

Machine Learning Model Improves Mortality Risk Prediction for Cardiac Surgery Patients

Machine learning algorithms have been deployed to create predictive models in various medical fields, with some demonstrating improved outcomes compared to their standard-of-care counterparts.... Read more

Point of Care

view channel
Image: The new eye-safe laser technology can diagnose traumatic brain injury (Photo courtesy of 123RF)

Novel Diagnostic Hand-Held Device Detects Known Biomarkers for Traumatic Brain Injury

The growing need for prompt and efficient diagnosis of traumatic brain injury (TBI), a major cause of mortality globally, has spurred the development of innovative diagnostic technologies.... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.