We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

Microbubble Technology Releases Oxygen on Demand

By HospiMedica International staff writers
Posted on 06 Aug 2021
Print article
Image: The Augmented Respiration Technology (ART) 500 system (Photo courtesy of Inspira Technologies)
Image: The Augmented Respiration Technology (ART) 500 system (Photo courtesy of Inspira Technologies)
A stable polymeric microbubble (MB) platform that releases Oxygen (O2) on demand could help prevent blood clotting during dialysis and blood oxidation therapies.

The Inspira Technologies (Ra'anana, Israel) MB platform, which was developed in conjunction with Ben-Gurion University (BGU; Beer Sheva), integrates into the Augmented Respiration Technology (ART) 500, a compact extracorporeal blood oxygenation system that is designed to oxygenate one liter of blood in one minute, rebalancing a patients' O2 saturation levels to a safe level of 95% or higher while they are awake and mobile, thus preventing the need for medically induced comas and intubation.

The polymeric MBs include an O2 gas core and a polylactic-co-glycolic acid (PLGA) shell synthesized by a modified double emulsion solvent evaporation method. As the MBs release their O2 load on demand, they can be used extend the life of oxidizers, thus potentially preventing the blood clotting resulting from required anticoagulant use during invasive O2 therapy. While still under development, MB technology (once fully integrated into the ART system), could be suitable to serve as an adjunct to dialysis and compatible with other blood oxidation systems.

“The use of anticoagulants for preventing blood clotting during invasive oxygen therapy is standard procedure, despite these drugs posing a high risk,” said Udi Nussinovitch, MD, PhD, Co-Founder and chief scientific officer of Inspira. “The joined technologies are intended to use innovative molecular approaches and novel oxygenation methods that have the potential to improve patients' outcomes.”

Oxygen saturation (SpO2) is the fraction of O2-saturated hemoglobin relative to total hemoglobin in the blood, with normal arterial blood oxygen saturation levels in humans are 95–100%. If the level is below 90%, it is considered hypoxemia. SpO2 levels below 80% may compromise organ function, such as the brain and heart, and should be promptly addressed. Continued low oxygen levels may lead to respiratory or cardiac arrest.

Related Links:

Inspira Technologies
Ben-Gurion University

Print article



view channel

44th IHF World Hospital Congress Presents Over 60 Plenary Sessions and 200 Renowned Speakers Across Four-Day Event

The 44th World Hospital Congress organized by The International Hospital Federation (Geneva, Switzerland) will bring together more than 200 healthcare experts, leading industry thinkers, and best practice... Read more
Copyright © 2000-2021 Globetech Media. All rights reserved.