We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
GLOBETECH PUBLISHING LLC

Siemens Healthineers - Laboratory Diagnostics

Provides advanced laboratory diagnostics solutions for the medical industry read more Featured Products: More products

Download Mobile App




Events

ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

Simple Blood Test Assesses Prognosis of Advanced Liver Fibrosis in NASH Patients

By HospiMedica International staff writers
Posted on 17 Jun 2022
Print article
Image: ELF test has been strongly recommended in 2022 AACE NAFLD guidelines (Photo courtesy of Siemens Healthineers)
Image: ELF test has been strongly recommended in 2022 AACE NAFLD guidelines (Photo courtesy of Siemens Healthineers)

Non-alcoholic fatty liver disease (NAFLD) refers to a spectrum of diseases, from simple fatty liver to more-aggressive nonalcoholic steatohepatitis (NASH). While patients with NASH are more likely to develop progressive disease, which can result in cirrhosis, liver failure, or hepatocarcinoma (HCC), patients without histological evidence of NASH are also at risk. Progressive chronic liver disease (CLD) typically lacks signs and symptoms, with many patients remaining undiagnosed until uncompensated disease presents. Liver fibrosis versus the inflammatory process is recognized as the key driver of pathogenicity in NAFLD/NASH. Early recognition of progressive fibrosis and intervention is key for improved outcomes. Now, a non-invasive blood test that measures three direct markers of fibrosis provides a direct quantitative measure for the assessment of disease progression in patients with advanced fibrosis due to NASH.

The Enhanced Liver Fibrosis (ELF) Test from Siemens Healthineers (Erlangen, Germany) is the first routine, standardized, direct-biomarker panel for prognostic risk assessment in advanced fibrosis due to NASH. The ELF Test can assess active, dynamic fibrosis rather than the damage it has caused, allowing it to be used as a prognostic marker to identify the patients most at risk of progression to cirrhosis and LREs in patients with advanced fibrosis due to NASH. The ELF score combines three serum biomarkers, namely Hyaluronic acid (HA), Procollagen III N-terminal peptide (PIIINP) and Tissue inhibitors of metalloproteinase (TIMP-1). The three direct markers of the ELF test are complementary and, when combined into an ELF score, provide information that is prognostic for progression to cirrhosis and liver-related events.

Being a blood-based test, the ELF Test can readily support high-volume testing, does not require patient access to specialized imaging equipment or highly trained operators, and generally has lower incidence rates of failure and unreliable results reported for imaging modalities. The ELF Test provides healthcare professionals with access to non-invasive testing through a simple blood test available to all patients, including those with type 2 diabetes mellitus and obesity. It allows them to improve patient care by stratifying advanced NASH patients most at risk of progressing to cirrhosis and liver-related events as well as enhance patient management with a blood test that facilitates more frequent prognostic assessments.

The ELF Test is now included in the 2022 AACE NAFLD Clinical Practice Guidelines to help stratify NASH patients most at risk for progression to cirrhosis. The guideline underscores the value of utilizing direct blood-based biomarkers in the NASH care continuum and represents an opportunity to incorporate preventative care to address the anticipated tsunami of patients from developing cirrhosis or life-threatening liver related events.

Related Links:
Siemens Healthineers 


Print article

Channels

AI

view channel
Image: ‘Hologram patients’ developed to help train doctors and nurses (Photo courtesy of University of Cambridge)

Life-Like Hologram Patients Train Doctors for Real-Time Decision Making in Emergencies

A medical training project using 'mixed reality' technology aims to make consistent, high-level and relevant clinical training more accessible across the world. University of Cambridge (Cambridge, UK)... Read more

Critical Care

view channel
Image: Tired doctors often leave patients in unnecessary pain, according to an Israeli study (Photo courtesy of Pexels)

Tired Night-Shift Physicians Less Likely to Prescribe Painkiller for Patients

A new study has revealed that physicians are far less likely to prescribe painkillers at night than during the day, indicating that the tiredness experienced by doctors is actually hurting patients.... Read more

Surgical Techniques

view channel
Image: The Senhance surgical system with digital laparoscopy (Photo courtesy of Asensus Surgical)

Digital Laparoscopic Platform Leverages Augmented Intelligence and Machine Learning

Challenges in laparoscopic surgery can impact cost, utilization, effectiveness, and outcomes of the procedure. For instance, the inability of the surgeon to control vision can create efficiency and safety... Read more

Patient Care

view channel
Image: The biomolecular film can be picked up with tweezers and placed onto a wound (Photo courtesy of TUM)

Biomolecular Wound Healing Film Adheres to Sensitive Tissue and Releases Active Ingredients

Conventional bandages may be very effective for treating smaller skin abrasions, but things get more difficult when it comes to soft-tissue injuries such as on the tongue or on sensitive surfaces like... Read more

Health IT

view channel
Image: AI can reveal a patient`s heart health (Photo courtesy of Mayo Clinic)

AI Trained for Specific Vocal Biomarkers Could Accurately Predict Coronary Artery Disease

Earlier studies have examined the use of voice analysis for identifying voice markers associated with coronary artery disease (CAD) and heart failure. Other research groups have explored the use of similar... Read more

Business

view channel
Image: Expanding the role of autonomous robots can mitigate the shortage of physicians (Photo courtesy of Pexels)

Robot-Assisted Surgical Devices Market Driven by Increased Demand for Patient-Specific Surgeries

An aging population and accompanying retirements will cause a significant physician shortfall of 55,000 to 150,000 by 2030, creating a gap in the healthcare system. Expanding the role of autonomous robots... Read more
Copyright © 2000-2022 Globetech Media. All rights reserved.